Short, Simple, Exercise to Improve Circadian Dependent Postprandial Glycemic Responses

Postprandial Hyperglycemia Clinical Trial

Official title:

Effects of Stair Stepping on Late Day Postprandial Glycemia

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05783752
• Other study ID #: HS-2023-0003
• Status: Recruiting
• Phase: N/A
• Start date: February 20, 2023
• Est. completion date: July 30, 2024

Study information

• Verified date: April 2024
• Source: San Diego State University
• Contact: Jochen Kressler, PhD
• Phone: (619) 594-0323
• Email: jkressler[@]sdsu.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to test whether one minute of stair stepping at a comfortable pace can reduce blood sugar after meals. The main objectives of the study are:

Compare continuously measured post-meal glucose after stair-stepping to control condition Compare continuously measured post-meal glucose after stair-stepping between meals Assess interaction between condition and meal to determine if the effect of stair-stepping on post-meal glucose depends on meal

Participants will be in the study for 10 days and will be asked to:

Wear a continuous glucose monitor over the course of the study Perform either one minute of comfortable pace stair stepping 15 min after each meal OR no exercise 1 hour after eating a meal on alternating days Perform a dietary recall every two days Perform no exercise within one hour after each meal on any day during the study Consume no calories within one hour after each meal during the study

Description:

After being informed about the study and potential risks, all participants giving written informed consent will undergo a screening to determine eligibility for study entry. At day 1, patients who meet the eligibility requirements will be randomly assigned to Arm 1(stair stepping day followed by no exercise day sequence) or Arm 2(no exercise day followed by stair stepping day sequence). At this time participants will also be familiarized with the continuous glucose (i.e., blood sugar) monitor they will wear for ten days, be instructed how to fill out a food log every day and determine a comfortable stair stepping pace. On day 10 participants will return to the lab for sensor removal and transmitter return.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 35
• Est. completion date: July 30, 2024
• Est. primary completion date: July 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• between 18 and 65 years

• able to climb and descend stairs

• access to stairs

Exclusion Criteria:

• glycemic medications that vary in dosage

• dosage from meal to meal or day to day (eg insulin titrated to meal size or carbohydrate content)

Related Conditions & MeSH terms

• Hyperglycemia
• Postprandial Hyperglycemia

Intervention

Behavioral:
• Stair Stepping
1 minute of stair-stepping (30 seconds up, 30 seconds down) at a self-selected pace identified on day 0 starting 15 minutes after each meal
• No exercise control
Participants avoid exercise within 1 hour of eating a meal

Locations

Country	Name	City	State
United States	San Diego State University	San Diego	California

Sponsors (1)

Lead Sponsor	Collaborator
San Diego State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postprandial Blood Glucose	mg/dL	continuous measure from meal consumption up to 1 hour post meal