Postpartum Hypertension Study

Status Not yet recruiting

Clinical Trial Summary

The purpose of this study is to assess which blood pressure medication (intravenous labetalol or oral nifedipine) works better in treating severely elevated blood pressure in women who have just delivered a baby.

Clinical Trial Description

Hypertensive emergencies cause significant maternal morbidity and mortality in the postpartum period. In order to reduced these risks, the recommendation is to treat women with severe range blood pressure with either intravenous labetalol or oral nifedipine; it is unclear which medication is superior. The objective of this study is to prospectively enroll women who have hypertensive emergencies in the postpartum period; women will be randomized in a 1:1 fashion and treated with one of the two antihypertensives to see which one works better. ;

Study Design

Related Conditions & MeSH terms

Emergencies
Hypertension
Hypertension, Malignant
Hypertension, Pregnancy-Induced
Hypertensive Crisis
Hypertensive Emergency
Postpartum Preeclampsia
Postpartum Pregnancy-Induced Hypertension
Pre-Eclampsia

Clinical Trial Details

NCT number	NCT05139238
Study type	Interventional
Source	Columbia University
Contact	Whitney A. Booker, MD
Phone	212-305-7334
Email	wb2322@cumc.columbia.edu
Status	Not yet recruiting
Phase	Phase 4
Start date	August 2024
Completion date	January 1, 2026

View Details

See also
Status	Clinical Trial	Phase
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Completed	`NCT03613714` - Innovation in Postpartum Care for Women With Hypertensive Disorders of Pregnancy	N/A
Completed	`NCT04752475` - Lasix for the Prevention of De Novo Postpartum Hypertension	Phase 3
Active, not recruiting	`NCT05049616` - Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension	Phase 4
Recruiting	`NCT03298802` - Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide	Phase 3
Recruiting	`NCT05849103` - Comprehensive Postpartum Management for Women With Hypertensive Disorders of Pregnancy	N/A
Completed	`NCT05775744` - Management of Postpartum Preeclampsia	N/A
Not yet recruiting	`NCT06310720` - Postpartum Video Education in High Risk Populations	N/A
Recruiting	`NCT05309460` - Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial	Phase 4
Completed	`NCT05159726` - Postpartum Video Education	N/A
Completed	`NCT03749746` - Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia	N/A
Completed	`NCT04236258` - Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period	Phase 4
Recruiting	`NCT03449277` - Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension	Phase 4
Completed	`NCT04222855` - Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients With Severe Preeclampsia	N/A