Postoperative Pain Clinical Trial
Official title:
Comparison of Intra-articular Dexmedetomidine and Magnesium in Postoperative Pain
Verified date | November 2018 |
Source | Derince Training and Research Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Arthroscopic meniscus surgeries are the most frequent orthopedic procedures. The objective of the study is to compare the effects of intraarticular local anesthetic and adjuvant (dexmedetomidine vs magnesium) combinations in postoperative pain and analgesic requirement. The investigators' hypothesis is adjuvants added to the local anesthetics decreases the total local anesthetic dose, provides more effective pain relief according to local anesthetic only, and decreases the postoperative systemic non-steroidal analgesic and opioid doses.
Status | Completed |
Enrollment | 62 |
Est. completion date | August 1, 2018 |
Est. primary completion date | July 1, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - age >18, <65 - scheduled for elective knee arthroscopy under spinal anesthesia - ASA I and ASA II Exclusion Criteria: - age <18 and >65 - patients who received general anesthesia - diabetes - refusal of the patient - known allergy to the specified drugs |
Country | Name | City | State |
---|---|---|---|
Turkey | Derince Training and Research Hospital | Kocaeli | Derince |
Lead Sponsor | Collaborator |
---|---|
Derince Training and Research Hospital |
Turkey,
Alipour M, Tabari M, Faz RF, Makhmalbaf H, Salehi M, Moosavitekye SM. Effect of dexmedetomidine on postoperative pain in knee arthroscopic surgery; a randomized controlled clinical trial. Arch Bone Jt Surg. 2014 Mar;2(1):52-6. Epub 2014 Mar 15. — View Citation
Gerlach AT, Dasta JF. Dexmedetomidine: an updated review. Ann Pharmacother. 2007 Feb;41(2):245-52. Epub 2007 Feb 13. Review. Erratum in: Ann Pharmacother. 2007 Mar;41(3):530-1. — View Citation
Heydari SM, Hashemi SJ, Pourali S. The Comparison of Preventive Analgesic Effects of Ketamine, Paracetamol and Magnesium Sulfate on Postoperative Pain Control in Patients Undergoing Lower Limb Surgery: A Randomized Clinical Trial. Adv Biomed Res. 2017 Oct — View Citation
Kizilcik N, Özler T, Menda F, Uluçay Ç, Köner Ö, Altintas F. The effects of intra-articular levobupivacain versus levobupivacain plus magnesium sulfate on postoperative analgesia in patients undergoing arthroscopic meniscectomy: A prospective randomized c — View Citation
Li C, Qu J. Efficacy of dexmedetomidine for pain management in knee arthroscopy: A systematic review and meta-analysis. Medicine (Baltimore). 2017 Oct;96(43):e7938. doi: 10.1097/MD.0000000000007938. Review. — View Citation
Sun R, Zhao W, Hao Q, Tian H, Tian J, Li L, Jia W, Yang K. Intra-articular clonidine for post-operative analgesia following arthroscopic knee surgery: a systematic review and meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2014 Sep;22(9):2076-84. doi: — View Citation
Yang Y, Zeng C, Wei J, Li H, Yang T, Deng ZH, Li YS, Yang TB, Lei GH. Single-dose intra-articular bupivacaine plus morphine versus bupivacaine alone after arthroscopic knee surgery: a meta-analysis of randomized controlled trials. Knee Surg Sports Traumat — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Postoperative Pain | postoperative pain scores (rest and movement) (ward) Pain scores were assessed with a 10-cm Visual Analogue Scale (VAS) (with 0 = no pain and 10 = the worst imaginable pain) | 24 hours | |
Secondary | Postoperative Opioid/NSAID Consumption | nonsteroid antiinflammatory drugs (NSAID) or opioid drugs that are applied to patients will be noted. | 24 hours | |
Secondary | Rescue Analgesic Time | Time to first analgesic demand at the orthopedics ward (from intraarticular injection to first analgesic requirement) | 24 hours | |
Secondary | Surgery Time | time from skin incision to closure | 24 hours | |
Secondary | Time to the End of Spinal Anesthesia | time from the start of spinal anesthesia (total block = Bromage 3) to the end of spinal anesthesia (Bromage 0) | 24 hours | |
Secondary | Mobilization | First mobilization time after surgery | 24 hours | |
Secondary | Number of Participants With Complications Due to Intraarticular Injection | post-injection complications due to intraarticular injection will be noted. | 24 hours |
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