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Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery — PESTI  

Postoperative Ileus Clinical Trial

Official title:
Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery (PESTI Trial)

Clinical Trial Summary

A double blind, placebo controlled, randomized control trial studying the safety and efficacy of pyridostigmine as a rescue therapy for postoperative ileus. Patients who undergo elective colorectal resection with or without creation of an ostomy, and subsequently develop postoperative ileus will be eligible for enrollment. Patients will be randomized to receive either pyridostigmine or placebo in addition to the current elements of standard of care. Patients will also complete the pyridostigmine bromide side effects scale (PBSES) upon enrollment and following each administration of either intervention or placebo to monitor treatment safety and evaluate for the development of side effects.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05334485
Study type Interventional
Source The Cleveland Clinic
Contact Stefan D Holubar
Phone 2164447000
Email holubas@ccf.org
Status Not yet recruiting
Phase Phase 2/Phase 3
Start date December 2024
Completion date January 2026
View Details
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