Disrupting Fear-based Memory Consolidation

Status Recruiting

Clinical Trial Summary

This project represents a unique collaborative opportunity to pursue the essential proof-of-principle demonstration that non-invasive interference of sensory cortical memory consolidation shortly after an emotional experience can attenuate the cued fear response and potentially reduce the risk of developing post-traumatic stress disorder (PTSD). If successful, the study results would anchor a potential advance in the treatment of patients after a traumatic event and seed future animal and clinical studies of emotional sensory cortical memory consolidation to reduce the prevalence and negative sequelae of PTSD.

Clinical Trial Description

This mechanistic study in humans will study an unexplored precision-based approach of non-invasive neuromodulation of sensory cortex with the aim to prevent PTSD by attenuating the sensory encoding of fear memory. The objective of this project is to explore the basic science and therapeutic potential of sensory-emotional reprogramming in humans, and translate this idea into a precise, individualized treatment to reduce the risk that negative emotional sensory experiences lead to PTSD. Understanding sensory-emotional programming in humans could anchor a breakthrough in the treatment of patients after a traumatic event and seed future animal and clinical studies of emotional sensory cortical memory consolidation to reduce the prevalence and negative sequela of PTSD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05560113
Study type	Interventional
Source	Emory University
Contact	Michael Borich, PhD
Phone	404-712-5512
Email	michael.borich@emory.edu
Status	Recruiting
Phase	N/A
Start date	November 28, 2022
Completion date	December 2028

View Details

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