Post-Traumatic Stress Disorder Clinical Trial
Official title:
Comparative Study of the Efficacy of a Cognitive-Behavioral Therapy for Post-Traumatic Stress Disorder With or Without D-Cycloserine
The purpose of this study is to investigate if the effectiveness of cognitive-behavioral therapy for post-traumatic stress disorder can be increased by combining it with D-cycloserine (TCC/D-cycloserine) by comparing with a placebo (TCC/placebo).
Status | Recruiting |
Enrollment | 20 |
Est. completion date | July 2008 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Clinical diagnosis of PTSD - No other Axix I disorder of higher intensity than PTSD - Accept not to start a psychopharmacological treatment before and during the participation to the project Exclusion Criteria: - Substance abuse - Psychotic episodes (past or current) - Bipolar disorder - Organic caused mental disorder - Intellectual deficiency - Pregnant or breast-feeding woman - Épilepsy |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Canada | Centre d'étude sur le Trauma | Montréal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Université de Montréal | Centre de recherche Fernand-Seguin, Hôpital Louis-H. Lafontaine |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinician-administered measures collected at initial assessment, post-treatment and six-months follow-up: | |||
Primary | CAPS: PTSD symptoms | |||
Primary | SCID: AXIS I disorders | |||
Secondary | Patient self-report forms collected at initial assessment, post-treatment and six-months follow-up: | |||
Secondary | BDI: depression symptoms | |||
Secondary | BAI: anxiety symptoms | |||
Secondary | WHOQL-Bref: quality of life |
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