Post Traumatic Stress Disorder Clinical Trial
Official title:
Combined Treatment With a Benzodiazepine (Clonazepam) and a Selective Serotonin Reuptake Inhibitor (Paroxetine) for Rapid Treatment of Posttraumatic Stress Disorder (PTSD)
Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder that follows exposure to an
extremely traumatic stressors. PTSD is associated with serious symptoms. While numerous
approaches have been used to treat PTSD, these treatments have several limiting factors.
This study will evaluate a combination of the drugs clonazepam and paroxetine for the
treatment of PTSD symptoms.
The main goal of treatment in patients with PTSD is to significantly reduce symptom severity
and improve functioning. While numerous approaches have been used to treat PTSD, these
treatments are limited by variable response rates, up to a 6-week lag period before clinical
response, and sub-optimal side effect profile, including possible worsening of anxiety and
insomnia prior to clinical response. The proposed study will examine whether combined
treatment with a benzodiazepine (clonazepam) and a selective serotonin reuptake inhibitor
(paroxetine) in patients with PTSD will accelerate the onset of clinical response. A second
goal is to evaluate whether the rapid and clinically meaningful benefits are sustained until
the end of the study, despite tapering off the benzodiazepine at the midpoint of the study.
The safety and tolerability of a combination of paroxetine and clonazepam will be compared
to paroxetine and placebo (an inactive pill) in the treatment of PTSD.
Participants in this study will be randomly assigned to receive either paroxetine plus
clonazepam or paroxetine plus a placebo for 12 weeks. Participants will have weekly clinic
visits for the first 4 weeks of the study and every other week for the last 8 weeks.
Symptoms of PTSD, anxiety, and depression will be evaluated and drug side effects will be
noted during the follow-up visits.
Posttraumatic Stress Disorder (PTSD) is an anxiety disorder (DSM IV) (American Psychiatric
Association) that follows exposure to an extremely traumatic stressor in which an individual
experienced, witnessed, or was confronted with actual or threatened death or serious injury
to self or others. The main goal of treatment in patients with PTSD is to significantly
reduce symptom severity across reexperiencing, avoidance and hyperarousal symptoms along
with improvement in function. While numerous approaches have been used to treat PTSD, these
treatments are limited by variable response rates, up to a 6-week lag period prior to the
onset of clinical response, and sub-optimal side effect profile, including possible
worsening of anxiety and insomnia prior to clinical response.
The proposed double blind study will examine whether combined treatment with a
benzodiazepine (clonazepam) and selective serotonin reuptake inhibitor (SSRI) (paroxetine)
in patients with PTSD will accelerate the onset of clinical response. A second goal is to
evaluate whether the rapid and clinically meaningful benefits are sustained until the end of
the study, despite tapering off the benzodiazepine at the midpoint of the study. The safety
and tolerability of a combination of paroxetine and clonazepam will be compared to
paroxetine and placebo in the treatment of PTSD.
We hypothesize that treatment with a combination of clonazepam and paroxetine will result in
a rapid reduction of PTSD symptoms compared to treatment with placebo and paroxetine. We
also propose that this accelerated reduction of symptoms will be sustained until the
end-point of the study, despite tapering off the benzodiazepine at the midpoint of the
study.
;
Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05915013 -
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
|
Phase 1 | |
Recruiting |
NCT05563805 -
Exploring Virtual Reality Adventure Training Exergaming
|
N/A | |
Recruiting |
NCT05934162 -
Efficacy of Internet-delivered Cognitive-behavior Therapy for PTSD
|
N/A | |
Recruiting |
NCT05934175 -
Intensive Treatment Versus Standard Weekly Prolonged Exposure for Adults With Post-Traumatic Stress Disorder
|
N/A | |
Completed |
NCT04460014 -
Simple Cognitive Task Intervention After Trauma During COVID-19 In Hospital Staff EKUT-P RCT
|
N/A | |
Completed |
NCT05877807 -
Effect of Baclofen to Prevent Post-Traumatic Stress Disorder
|
||
Active, not recruiting |
NCT05992649 -
The Effect of Aquatic Physiotherapy on Veterans Suffering From PTSD - a 40-week Pilotproject
|
N/A | |
Terminated |
NCT04404712 -
FAAH Availability in Psychiatric Disorders: A PET Study
|
Early Phase 1 | |
Not yet recruiting |
NCT05331534 -
Effect of Attentional Therapy on Post-traumatic Stress Disorder
|
N/A | |
Not yet recruiting |
NCT03649607 -
Accelerated Resolution Therapy for HIV Positive African, Caribbean and Black
|
N/A | |
Not yet recruiting |
NCT04076215 -
Biochemical and Physiological Response to Stressogenic Stimuli
|
N/A | |
Not yet recruiting |
NCT02545192 -
A Pilot Study of Low Field Magnetic Stimulation in PTSD: Three Daily Treatments
|
Phase 1 | |
Completed |
NCT02329418 -
Written Document to Assist Family During Decision of Withholding and Withdrawing Life-sustaining Therapies in the Intensive Care Unit
|
N/A | |
Active, not recruiting |
NCT00978484 -
A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder
|
Phase 3 | |
Completed |
NCT00760734 -
Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)
|
Phase 1 | |
Completed |
NCT03278171 -
Early Detection of Patients at Risk of Developing a Post-traumatic Stress Disorder After a Stay in Intensive Care Unit
|
||
Recruiting |
NCT05874362 -
People Bereaved by Violent Death : Negative Event Biases and Temporal Perception
|
N/A | |
Terminated |
NCT03898843 -
Assisted Animal Therapy: ReAnimal
|
N/A | |
Recruiting |
NCT04747379 -
Psychological Effect of Explicit Recall After Sedation (PEERS)
|
||
Completed |
NCT03248167 -
Cannabidiol as a Treatment for AUD Comorbid With PTSD
|
Phase 1/Phase 2 |