Post Traumatic Stress Disorder Clinical Trial
Official title:
Psychological Impact in a Relative, Following the Announcement of the Death of a Loved One After Cardiac Arrest and the Early Request for Organ Donation: an Observational, Prospective Study
The fight against the scarcity of grafts is a major public health issue in France. Despite a
very good success rate of transplants from brain-dead donors or living donors, the waiting
time for transplantation continues to increase, leading to morbidity and mortality, as well
as medical costs. Since 2005, the BioMedicine Agency has implemented a protocol authorizing
kidney and liver samples taken from deceased donors after cardiac arrest (DDAC). This type of
sampling has become a common practice in several regions of France and Europe. In case of
DDAC, the sampling protocol poses a significant temporal constraint, since the patient must
be taken within 6 hours after the cardiac arrest. This constraint leads to a specific
organization of the announcement of the death and the request for non-opposition to the levy.
The brutal loss of a loved one is a potentially traumatic experience for family members. The
manifestations of the pathological components of mourning such as post-traumatic stress
disorder, anxio-depressive syndrome, pathological bereavement, are often expressed early in
the first year after the death of the loved one. Families of organ donor patients probably
represent a population at high risk for the expression of psychiatric conditions such as
post-traumatic stress disorder or pathological bereavement. The limited time available to
prepare relatives to make a decision could promote the expression of psychiatric morbidity in
the short or medium term. The data on this new transplantation procedure and its
psychological consequences are insufficient, and we consider that if a state of
post-traumatic stress occurred in more than 50% of parents, the procedure of announcement
would be reviewed. The purpose of this study is to test this hypothesis.
Most of the work on relatives of potential organ donors has focused on procedures for brain
death. Most of this work has focused on characterizing the determinants of acceptance or
refusal of organ donation in the family. The literature relating to the follow-up of
relatives of a patient after organ donation is very poor: very few studies have focused on
the psychological consequences and / or the psychological state of this population in the
period post-death. In addition, very few qualitative and quantitative studies make it
possible to evaluate the appearance of psychopathological manifestations related to the
announcement of death simultaneously with a request for organ removal. This research,
therefore, will make it possible to estimate the possible psychological impact on the
bereaved family as well as an assessment of the psychological state. A mixed methodology
(quantitative and qualitative) will make it possible to highlight explanatory factors of the
quantitative results.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05915013 -
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
|
Phase 1 | |
| Recruiting |
NCT05563805 -
Exploring Virtual Reality Adventure Training Exergaming
|
N/A | |
| Recruiting |
NCT05934162 -
Efficacy of Internet-delivered Cognitive-behavior Therapy for PTSD
|
N/A | |
| Recruiting |
NCT05934175 -
Intensive Treatment Versus Standard Weekly Prolonged Exposure for Adults With Post-Traumatic Stress Disorder
|
N/A | |
| Completed |
NCT04460014 -
Simple Cognitive Task Intervention After Trauma During COVID-19 In Hospital Staff EKUT-P RCT
|
N/A | |
| Completed |
NCT05877807 -
Effect of Baclofen to Prevent Post-Traumatic Stress Disorder
|
||
| Active, not recruiting |
NCT05992649 -
The Effect of Aquatic Physiotherapy on Veterans Suffering From PTSD - a 40-week Pilotproject
|
N/A | |
| Terminated |
NCT04404712 -
FAAH Availability in Psychiatric Disorders: A PET Study
|
Early Phase 1 | |
| Not yet recruiting |
NCT05331534 -
Effect of Attentional Therapy on Post-traumatic Stress Disorder
|
N/A | |
| Not yet recruiting |
NCT04076215 -
Biochemical and Physiological Response to Stressogenic Stimuli
|
N/A | |
| Not yet recruiting |
NCT03649607 -
Accelerated Resolution Therapy for HIV Positive African, Caribbean and Black
|
N/A | |
| Not yet recruiting |
NCT02545192 -
A Pilot Study of Low Field Magnetic Stimulation in PTSD: Three Daily Treatments
|
Phase 1 | |
| Completed |
NCT02329418 -
Written Document to Assist Family During Decision of Withholding and Withdrawing Life-sustaining Therapies in the Intensive Care Unit
|
N/A | |
| Active, not recruiting |
NCT00978484 -
A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder
|
Phase 3 | |
| Completed |
NCT00760734 -
Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)
|
Phase 1 | |
| Completed |
NCT03278171 -
Early Detection of Patients at Risk of Developing a Post-traumatic Stress Disorder After a Stay in Intensive Care Unit
|
||
| Recruiting |
NCT05874362 -
People Bereaved by Violent Death : Negative Event Biases and Temporal Perception
|
N/A | |
| Terminated |
NCT03898843 -
Assisted Animal Therapy: ReAnimal
|
N/A | |
| Recruiting |
NCT04747379 -
Psychological Effect of Explicit Recall After Sedation (PEERS)
|
||
| Completed |
NCT03248167 -
Cannabidiol as a Treatment for AUD Comorbid With PTSD
|
Phase 1/Phase 2 |