Post-stroke Elbow Spasticity Clinical Trial
Official title:
Assesment of Post-stroke Elbow Flexor Spasticity in Response to Passive Stretch in Different Forearm Positions
Determination of which muscle is more spastic before injection of the botulinum toxin, and
the application of the targeted treatment to that muscle results in more improvement in
spasticity. It is known that the muscles that flex elbow in healthy individuals change
according to forearm position. While the biceps brachii flexes the forearm in supination, the
brachioradialis flexes the forearm in the neutral position. The brachialis muscle acts as a
primary flexor muscle when the forearm is in pronation.
In this study, hypothesis is that the severity of spasticity differs depending on the forearm
position.
There are three main muscles that contribute to elbow flexor spasticity; musculus biceps
brachii, musculus brachialis and musculus brachioradialis. Muscle selection in elbow flexor
spasticity for botulinum toxin application has impact on treatment outcome. The
superficiality of the biceps brachii muscle makes it an easy target for botulinum toxin
injection. In dynamic electromyography studies, it has been reported that brachioradialis
muscle is the most common contributor one to elbow flexion spasticity, followed by biceps
brachii muscle. In the diagnostic selective nerve blocks, the brachialis muscle has been
reported to be foreground.
Determination of which muscle is more spastic before injection of the botulinum toxin, and
the application of the targeted treatment to that muscle results in more improvement in
spasticity. Can the target muscle selection clinically be performed instead of methods such
as electromyography where equipment is required and the evaluation period is relatively long?
Can semi-quantitative methods used to assess the severity of spasticity provide reliable
information regarding the muscle or muscles that contribute to elbow flexor spasticity? It is
known that the muscles that flex elbow in healthy individuals change according to forearm
position. While the biceps brachii flexes the forearm in supination, the brachioradialis
flexes the forearm in the neutral position. The brachialis muscle acts as a primary flexor
muscle when the forearm is in pronation.
The aim of this study is to investigate whether the severity of spasticity differs depending
on the forearm position.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02358005 -
Optimal Dose of Extracorporeal Shock Wave Therapy After Botulinum Toxin Type A Injection for Post-stroke Spasticity
|
Phase 4 |