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NCT03463070 Clinical Trial

Misoprostol Before and After Cesarean Section

Post Partum Hemorrhage Clinical Trial

Official title:
The Effect of Misoprostol Given Preoperative Versus Postoperative on Blood Loss With Elective Cesarean Section: Randomized Controlled Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT03463070
Other study ID # 1122345
Secondary ID
Status Not yet recruiting
Phase Phase 3
First received March 4, 2018
Last updated March 12, 2018
Start date March 2018
Est. completion date September 2018

Study information
Verified date March 2018
Source Kasr El Aini Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

comparison of the effect of misoprostol before and after cesarean on the blood loss

Description:

70 women who received 600 mg misoprostol rectally preoperatively versus 70 women who received 600 mg misoprostol postoperatively at operating theatre

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 140
Est. completion date September 2018
Est. primary completion date September 2018
Accepts healthy volunteers No
Gender Female
Age group 20 Years to 35 Years
Eligibility Inclusion Criteria:

- Women not in active labor have reactive non-stress test.

- No contraindications to prostaglandins.

- Have no history of coagulopathy.

Exclusion Criteria:

- Placenta previa.

- Maternal hypertension.

- Diabetes mellitus.

- Previous CS and those with active labor.

- Multiple Fibroid uterus.

- Multiple pregnancies or polyhydramnios.

- Previous myomectomy, previous history of PPH.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• rectal misoprostol 600mg
70 women who received 600 mg misoprostol postoperatively at operating theatre

Locations
Country Name City State
Egypt Kasr El Ainiy Hospital Cairo

Sponsors (1)
Lead Sponsor Collaborator
sarah mohamed hassan

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary intraoperative blood loss Difference in weight of linen towels (gm)+Volume of contents of suction bottle (ml) the operation time
Primary postoperative blood loss weighing the soaked napkins after collection of soaked towel every 6 hours during first 24 hours.
See also
  Status Clinical Trial Phase
Completed NCT03680339 - The Effect of Preoperative and Post Operative Misoprostol Administration on Intraoperative Blood Loss and Postpartum Hemorrhage in CS Phase 4
Completed NCT03693599 - Carbetocin Versus Syntometrine in Obese Women Undergoing Elective Cesarean Phase 4
Completed NCT03707132 - Tourniquet Reduces Blood Loss in Postpartum Hemorrhage During Hysterectomy for Placenta Accreta
Recruiting NCT02306733 - Ergometrine Versus Oxytocin in the Management of Atonic Post-partum Haemorrhage (PPH) in Women Delivered Vaginally Phase 3
Completed NCT01866241 - Combating Maternal Mortality in Uganda: An Assessment of the Role of Misoprostol in Prevention of Post-Partum Hemorrhage Phase 3
Not yet recruiting NCT01236482 - Oxytocin in Cesarean Delivery Phase 4
Completed NCT03784794 - Patient Blood Management for Massive Obstetric Hemorrhage N/A
Recruiting NCT04401839 - Amr Maneuver for Prevention of Postpartum Hemorrhage N/A
Not yet recruiting NCT06219538 - DAISY Uterine Drain Device Evaluation N/A
Completed NCT01863706 - Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage Phase 1
Not yet recruiting NCT05488457 - Oxytocin Pharmacokinetics and Pharmacodynamics Phase 2
Completed NCT04723979 - NovoSeven® in Severe Postpartum Haemorrhage - Experiences From UK, DK, FR, NL
Terminated NCT04277962 - Estimating Blood Loss Using TritonTM in Vaginal Deliveries: A Validation Trial N/A
Completed NCT03570723 - Glove-loaded Foley's Catheter Tamponade for Cesarean Section for Placenta Previa N/A
Completed NCT03117647 - Mansoura-VV Uterine Compression Suture for Primary Atonic Postpartum Hemorrhage N/A
Active, not recruiting NCT03069859 - Use of TXA to Prevent Postpartum Hemorrhage Phase 2
Not yet recruiting NCT03891082 - A Comparative Study Between Bakri Balloon and B Lynch Suture Used to Control Primary Postpartum Hemorrhage After Cesarean Section N/A
Recruiting NCT05532215 - Sublingual Misoprostol in Reduction of Caesarean Blood Loss N/A
Not yet recruiting NCT06255496 - QStat Cartridge in Obstetric Patients
Completed NCT03907605 - Anti-Mullerian Hormone (AMH) is a Marker for Ovarian Reserve. There Are Many Studies About AMH Changes in Ovarian Surgery, But Little is Known for Other Surgeries. We Seek to Investigate the Hormone Variations Before and After Uterine Artey Ligation for Postpartum Hemorrage (PPH)