Post-operative Pain Clinical Trial
Official title:
A Double-blind, 5 Parallel-group, Placebo-controlled, Randomised, Single Dose, 3-site Study to Compare the Analgesic Efficacy and Tolerability of a Combination of Ibuprofen 400 mg Plus Paracetamol 1000 mg; a Combination of Ibuprofen 200 mg Plus Paracetamol 500 mg; a Combination of Ibuprofen 400 mg Plus Codeine 25.6 mg (Nurofen Plus®); a Combination of Paracetamol 1000 mg Plus Codeine 30 mg (Panadeine® Extra) in Postoperative Adult Dental Pain Following Third Molar Extraction.
The objective is to assess the efficacy and tolerability of a combination of 400 mg ibuprofen plus 1000 mg acetaminophen, 200 mg ibuprofen plus 500 mg acetaminophen compared with Nurofen Plus® and Panadeine® Extra.
RB has developed a fixed-dose combination of ibuprofen and acetaminophen (paracetamol). Since
the pharmacological actions of ibuprofen and acetaminophen (paracetamol) differ in their site
and mode of action, the combination would be expected to be more effective than either active
alone, given that pain is multi-factorial with different mediators.
The purpose of this study was to compare the efficacy and tolerability of
ibuprofen/acetaminophen (paracetamol) combination with leading market analgesics.
The efficacy and tolerability was assessed in terms of total analgesic effect, peak analgesic
effect, onset and duration of action and the subject's overall assessment of the study
medication.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02489526 -
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Colorectal Surgery
|
Phase 2 | |
| Terminated |
NCT05146453 -
Sternotomies and PectoIntercostal Fascia Blocks in Fast-Track Cardiac Anesthesiology
|
Phase 4 | |
| Completed |
NCT05635916 -
Trial of Liposomal Bupivacaine for TKA
|
Phase 4 | |
| Recruiting |
NCT06028126 -
Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial
|
N/A | |
| Not yet recruiting |
NCT03591172 -
Using Three Different Final Irrigants and Showing Their Effects on the Success of Revascularization
|
N/A | |
| Completed |
NCT01667445 -
Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty
|
Phase 4 | |
| Completed |
NCT01686802 -
Post-operative Oral Morphine Versus Ibuprofen
|
Phase 2 | |
| Completed |
NCT01444924 -
Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery
|
Phase 2 | |
| Completed |
NCT00830089 -
Trial of a Transversus Abdominis Plane (TAP) Block in Laparoscopic Colorectal Surgery
|
N/A | |
| Completed |
NCT00968955 -
Effect of Local Infiltration Analgesia in Total Hip Arthroplasty
|
Phase 4 | |
| Terminated |
NCT00875862 -
Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks
|
Phase 4 | |
| Completed |
NCT00847093 -
LMX-4 for Postoperative Pain Management in Infants and Children Undergoing Penoplasty Surgery
|
Phase 4 | |
| Completed |
NCT00390312 -
Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction
|
Phase 2 | |
| Recruiting |
NCT05278494 -
Dextromethorphan for Treatment of Postoperative Pain
|
N/A | |
| Recruiting |
NCT05973045 -
Investigation of the Effect of Distention Medium Temperature on Image Quality, Hyponatremia Risk, and Post-operative Pain in Operative Hysteroscopy
|
N/A | |
| Not yet recruiting |
NCT04999670 -
Fascial Closure and Post-caesarean Pain
|
N/A | |
| Enrolling by invitation |
NCT04346407 -
Dronabinol for Post-operative Pain After Lumbar Fusion
|
Phase 4 | |
| Completed |
NCT03635515 -
Occurrence of Post-op Pain Following Gentlewave
|
N/A | |
| Terminated |
NCT03201809 -
Comparison of Preoperative Ultrasound Guided Pectoralis Nerve Block Placement Versus Intra-operative Placement: A Prospective Randomized Trial
|
N/A | |
| Completed |
NCT03254056 -
Fascial Closure Techniques Post-Operative Pain Laparoscopy
|
N/A |