Initial Local Anesthetic Dose With Continuous Interscalene Analgesia

Status Completed

Clinical Trial Summary

Objective: To determine a minimally effective initial local anesthetic bolus required to provide satisfactory analgesia using continuous brachial plexus infusion following arthroscopic shoulder surgery using a double-blind, randomized, study comparing 3 initial doses.

Clinical Trial Description

Aims:

1. To compare pain ratings and supplemental analgesic requirements at discharge from PACU, 24 hours, and 48 hours and 12 weeks following 5, 10, and 20 ml boluses.

2. To compare adverse events including clinical dysphonia, Horner's syndrome, dyspnea, unexpected hospitalization, evidence of local anesthetic toxicity, and hand weakness at discharge from PACU following 5, 10, and 20 ml boluses.

3. To compare impairment in diaphragmatic excursion at discharge from PACU following 5, 10, and 20 ml boluses.

4. To compare patients' satisfaction with analgesia at 24 and 48 hours following 5, 10, and 20 ml boluses.

5. To compare patient rating of functional outcome at baseline and at 12 weeks following 5, 10, and 20 ml boluses.

6. To compare the rate of general anesthesia required following 5, 10, and 20 ml boluses. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00672100
Study type	Interventional
Source	William Beaumont Hospitals
Contact
Status	Completed
Phase	N/A
Start date	January 2009
Completion date	August 2010

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02489526` - Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Colorectal Surgery	Phase 2
Terminated	`NCT05146453` - Sternotomies and PectoIntercostal Fascia Blocks in Fast-Track Cardiac Anesthesiology	Phase 4
Completed	`NCT05635916` - Trial of Liposomal Bupivacaine for TKA	Phase 4
Recruiting	`NCT06028126` - Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial	N/A
Not yet recruiting	`NCT03591172` - Using Three Different Final Irrigants and Showing Their Effects on the Success of Revascularization	N/A
Completed	`NCT01667445` - Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty	Phase 4
Completed	`NCT01686802` - Post-operative Oral Morphine Versus Ibuprofen	Phase 2
Completed	`NCT01444924` - Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery	Phase 2
Completed	`NCT00830089` - Trial of a Transversus Abdominis Plane (TAP) Block in Laparoscopic Colorectal Surgery	N/A
Completed	`NCT00968955` - Effect of Local Infiltration Analgesia in Total Hip Arthroplasty	Phase 4
Terminated	`NCT00875862` - Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks	Phase 4
Completed	`NCT00847093` - LMX-4 for Postoperative Pain Management in Infants and Children Undergoing Penoplasty Surgery	Phase 4
Completed	`NCT00390312` - Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction	Phase 2
Recruiting	`NCT05278494` - Dextromethorphan for Treatment of Postoperative Pain	N/A
Recruiting	`NCT05973045` - Investigation of the Effect of Distention Medium Temperature on Image Quality, Hyponatremia Risk, and Post-operative Pain in Operative Hysteroscopy	N/A
Not yet recruiting	`NCT04999670` - Fascial Closure and Post-caesarean Pain	N/A
Enrolling by invitation	`NCT04346407` - Dronabinol for Post-operative Pain After Lumbar Fusion	Phase 4
Completed	`NCT03635515` - Occurrence of Post-op Pain Following Gentlewave	N/A
Terminated	`NCT03201809` - Comparison of Preoperative Ultrasound Guided Pectoralis Nerve Block Placement Versus Intra-operative Placement: A Prospective Randomized Trial	N/A
Completed	`NCT03254056` - Fascial Closure Techniques Post-Operative Pain Laparoscopy	N/A