Carvedilol vs. Propranolol in Second Prophylaxis of Variceal Bleeding

Status Not yet recruiting

Clinical Trial Summary

This randomized controlled trial was conducted to evaluate the efficacy and safety of carvedilol versus propranolol, combined with routine endoscopic treatment, in the secondary prophylaxis of variceal bleeding in patients with cirrhosis.

Clinical Trial Description

Non-selective beta blockers combined with endoscopic variceal band ligation (EVL) is the most effective methods for the prevention of variceal bleeding. Carvedilol has emerged as the preferred NSBB for treating portal hypertension in compensated cirrhosis due to strong evidence demonstrating that it has a more pronounced effect than propranolol to reduce the hepatic vein pressure gradient (HVPG), together with good patient acceptability and safety profile. However, No data from prospectively designed trials are available on the efficacy of carvedilol in the secondary prophylaxis of variceal bleeding. The aim of this randomized controlled trial was to evaluate the effectiveness and safety of carvedilol compared to propranolol as secondary prophylaxis of variceal bleeding in patients with cirrhosis. All cirrhotic patients with at least one episode of variceal bleeding were included and randomized to the carvedilol or propranolol groups. EVL protocol was routinely performed in both groups. Variceal rebleeding, further decompensation, liver-related death, and overall survival was the outcomes of this trial. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05651789
Study type	Interventional
Source	West China Hospital
Contact	Xuefeng Luo, M.D.
Phone	+8613880098212
Email	luo_xuefeng@wchscu.cn
Status	Not yet recruiting
Phase	N/A
Start date	January 2023
Completion date	December 2024

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