Portal Hypertension Clinical Trial
Official title:
Preliminary Efficacy And Tolerability Of Oral NCX-1000 After Repeated Administrations In Patients With Portal Hypertension: A Double-Blind Dose Escalating Study
Chronic liver diseases are often characterized by portal hypertension, a major complication
involving haemodynamic changes due to increased intrahepatic vascular resistance. It has
become well established that nitric oxide (NO) plays a crucial role in the haemodynamic
abnormalities that develop in chronic portal hypertension.
NCX-1000 is a NO-releasing derivative of ursodeoxycholic acid that would compensate for the
defective liver NO production in cirrhosis.
This study intends to demonstrate the desired therapeutic activity (reduction in portal
pressure) in a small number of target patients, to assess the safety and tolerability after
repeated oral administrations of NCX-1000, and to get preliminary pharmacokinetic data in
this population.
Brief summary is complete. Study is closed. ;
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