Polycystic Ovary Clinical Trial
Official title:
Clomiphene Citrate Stair-step Protocol for Ovulation Induction in Women With Polycystic Ovarian Syndrome: A Randomized Clinical Trial
A RCT will be conducted to compare the traditional clomiphene citrate regimens for ovulation induction with the stair-step protocol. Sixty women will be included after obtaining their written informed consent and will be randomized into either of the 2 groups.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | July 2018 |
Est. primary completion date | July 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 20 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Age between 20-35 years. - Body mass index (BMI/m2) 26-35 kg/m2 - Normal hystrosalpingogram (HSG). - Normal Prolactin level. - Normal semen analysis. Exclusion Criteria: - - They underwent ovarian drilling. - Other factors infertility. - AUTOimmune diseases as thyroid disorders and systemic lupus erythematosus. |
Country | Name | City | State |
---|---|---|---|
Egypt | Ain Shams University Maternity Hospital | Cairo |
Lead Sponsor | Collaborator |
---|---|
Ain Shams Maternity Hospital |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Occurrence of the ovulation by transvaginal ultrasound | Follicle suddenly disappears or regresses in size. Irregular margins. Intra follicular echos. Follicle suddenly becomes more echogenic. Free fluid in pouch of douglas. |
20 days | |
Secondary | time to achieve ovulation | time for ovulation to occur | 20 days | |
Secondary | dose of clomiphene to achieve ovulation | the total dose of clomiphene used till ovulation | 20 days |
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