Polycystic Ovary Clinical Trial
Official title:
Sodium-Glucose Co-Transporter-2 Inhibitors as Adjuvant Therapy With Letrozole in Induction of Ovulation in Women With Polycystic Ovarian Syndrome
The aim of the study is to assess the efficacy of adjuvant therapy dapagliflozin, metformin as monotherapy and combination of both in comparison to control group in induction of ovulation with letrozole in women PCOS, focusing specifically on rates of ovulation and pregnancy.
The study will be a randomized controlled clinical trial. Once the eligibility from screening visit is determined prior to baseline visit, randomization will be made by computer randomization for women who are admitted to Beni-Suef University Hospital. - Before initiation of the study, the population will be divided randomly into 4 equal groups: group A, B, C and D. The adjuvant therapy of each group will be group (A) Metformin 1000mg, group (B) Dapagliflozin 10mg, Group(C) Combined Dapagliflozin-Metformin 10/1000mg and group (D) with no adjuvant therapy (control group). - The adjuvant therapy will be taken once daily with a main meal and started one month before initiation of letrozole. All groups will take letrozole 2.5mg twice daily from the third day of the cycle for 5 days. This treatment regimen will continue for three cycles unless positive pregnancy is achieved. No diet restriction will be recommended during the study or change in the lifestyle. The population will be asked to inform about any side effects that may happen during the study. A written informed consent will be obtained from each woman participating in the study. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT06428786 -
The Effect of Polycystic Ovary Syndrome Phenotypes on Quality of Life and Sexual Function
|
||
| Not yet recruiting |
NCT05965908 -
Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome
|
Phase 3 | |
| Recruiting |
NCT03819998 -
Serum Fetuin Level in Polycystic Ovary Syndrome
|
||
| Completed |
NCT04231786 -
Breast Ultrasonography and Polycystic Ovary Syndrome
|
||
| Completed |
NCT04448730 -
Polycystic Ovary Syndrome and BETATROPHIN
|
||
| Completed |
NCT05062135 -
Progesterone Action on Endometrium of PCOS
|
N/A | |
| Recruiting |
NCT03178500 -
Clomiphene Citrate Stair-Step Protocol
|
N/A | |
| Completed |
NCT03871868 -
Vitamin D Levels And Myoma Uteri
|
||
| Recruiting |
NCT05452642 -
The Supporting Understanding of PCOS Education and Research (SUPER) Study
|
N/A | |
| Not yet recruiting |
NCT02087410 -
Serum Ghrelin in Polycystic Ovary Syndrome
|
N/A |