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Ovary Syndrome for Efficient Diagnosis and Targeted Therapy — PCOS-01  

Polycystic Ovary Syndrome Clinical Trial

Official title:
Understanding the Epigenetic Mechanisms in the Pathophysiology of Polycystic Ovary Syndrome for Efficient Diagnosis and Targeted Therapy

Clinical Trial Summary

OBJECTIVES: 1. Analysis of DNA methyl transferases (DNMT1, DNMT3A and DNMT3B) and Histone deacetylases (HDAC 1,2,3 and SIRTs) polymorphisms (Somatic and germ line variations). 2. Analysis of differential mRNA and protein expression of epigenetic markers in ovarian tissues obtained from PCOS patients. 3. miRNA regulated epigenetic mechanisms in PCOS 4. Epigenetic regulation of endocrine genes in PCOS DESIGN : A Case Control study.Sample size:200

Clinical Trial Description

1. We will take both blood and ovarian tissue samples used to diagnosis. 2. We will take approximately 3 ml of blood which will be used from the blood sample collected for routine preoperative tests (surgical profile) before their planned surgery or for disease evaluation. 3. Small tissue samples (from ovary) will be taken from the tissue which is surgically excised as a part of treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06102629
Study type Interventional
Source Asian Institute of Gastroenterology, India
Contact Shraddha Ramchandani
Phone 9182645727
Email drshraddhamohan@gmail.com
Status Not yet recruiting
Phase N/A
Start date November 5, 2023
Completion date November 15, 2026
View Details
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