Polycystic Ovary Syndrome Clinical Trial
Official title:
Randomized Controlled Trial Comparing the Effect of GnRH Agonist and Antagonist Ovarian Stimulation Protocols in PCOS Patients
The purpose of this study is to compare pregnancy rates and the occurrence of OHSS in PCOS patients who were treated with GnRH agonist and GnRH antagonist protocols ovarian stimulation during an IVF cycle. Our hypothesis is that the GnRH antagonist protocol reduces the occurrence and severity of OHSS compared to the GnRH agonist protocol.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | May 2007 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - Clinical diagnosis of PCOS (presence of oligo-ovulation/anovulation and polycystic ovaries) Exclusion Criteria: - Normal responders - Poor responders |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Greece | Eugonia | Athens |
Lead Sponsor | Collaborator |
---|---|
Eugonia |
Greece,
Aboulghar MA, Mansour RT. Ovarian hyperstimulation syndrome: classifications and critical analysis of preventive measures. Hum Reprod Update. 2003 May-Jun;9(3):275-89. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Development of OHSS | |||
Primary | Ongoing pregnancy rate per embryo transfer | |||
Secondary | Biochemical pregnancy | |||
Secondary | Clinical pregnancy | |||
Secondary | Embryological data |
Status | Clinical Trial | Phase | |
---|---|---|---|
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