Incretin Secretion in Women With Polycystic Ovary Syndrome (PCOS)

Status Terminated

Clinical Trial Summary

The incretin hormones are secreted from the gastrointestinal tract in response to nutrient ingestion, and are responsible for 70 % of insulin secretion in response to glucose. The incretin response is attenuated in subjects with type 2 diabetes and other conditions associated with insulin resistance. Polycystic ovary syndrome (PCOS) is characterised by irregular periods and increased androgen levels. It is the most common endocrine disorder amongst young women at fertile age, and the most common cause of female infertility. Insulin resistance plays an important role in the development of the disease, and women with PCOS are at increased risk of developing tyoe 2 diabetes. the incretin hormones have not previously been investigated in women with PCOS, and the purpose of the present study was to investigate the secretion of the two most important incretin hormones Glucose-like peptide-1 (GLP-1) and Glucose dependent insulinotropic peptide (GIP) during a three hour oral glucose tolerance test.

Clinical Trial Description

n/a

Study Design

Primary Purpose: Basic Science

Related Conditions & MeSH terms

Polycystic Ovary Syndrome

Clinical Trial Details

NCT number	NCT00647023
Study type	Interventional
Source	Hvidovre University Hospital
Contact
Status	Terminated
Phase	N/A
Start date	February 2004
Completion date	May 2006

View Details

See also
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