Clinical Trials Logo

Clinical Trial Summary

High ucOC may favor insulin release in lean hyperandrogenic women to compensate for impaired insulin sensitivity. Meformin is an insulin sensitizing agent will be given for these women trying to interfere with the pathophysiology of PCOS in these women as followed up by serum UC-OC levels.


Clinical Trial Description

Under-carboxylated osteocalcin (ucOC), the precursor substrate of bone biomarker OC is a potent regulator of energy metabolism by promoting insulin production and adiponectin synthesis and decreasing fat stores.UcOC has a potential role in the physiopathology of polycystic ovary syndrome (PCOS), a common disorder defined by the constellation of anovulation, insulinresistance, hyperinsulinemia, obesity and androgen excess.Circulating ucOC concentration is related to key endocrine PCOS characteristics in a weight-dependent manner. Within the bone-pancreas loop, high ucOC may favor insulin release in lean hyperandrogenic women to compensate for impaired insulin sensitivity.We will investigate serum uc-OC responses to insulin sensitizing therapies in lean hyperandrogenic polycystic ovary syndrome (PCOS). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02244567
Study type Interventional
Source Beni-Suef University
Contact Nesreen A Shehata, MD
Phone 00201227866337
Email nesoomar@yahoo.com
Status Recruiting
Phase Phase 1
Start date September 2014
Completion date June 2021

See also
  Status Clinical Trial Phase
Completed NCT01672801 - Nimodipine to Prevent LH Surge During Ovulation Induction: Blinded Placebo-controlled RCT N/A
Completed NCT01653743 - Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women Phase 3
Completed NCT00579540 - Compare Effects of Flax Seed Oil, and Fish Oil on Blood Sugar Levels N/A
Terminated NCT05084274 - Optimising Preconceptual Health in Subfertile PCOS Patients Using a Lifestyle Modification Program N/A
Completed NCT03717935 - Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS N/A
Withdrawn NCT01716429 - Healthy Eating for Reproductive Health: Greenville N/A
Active, not recruiting NCT02896452 - Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome
Recruiting NCT05146063 - LNK in Polycystic Ovary Syndrome With Insulin Resistance
Recruiting NCT06303219 - Effects of Traditional Moderate Intensity Training and High Intensity Interval Training in Polycystic Ovarian Syndrome N/A
Completed NCT02869750 - The Relationship Between Adipokines, Obesity and Insulin Resistance in Women With Polycystic Ovarian Syndrome
Completed NCT01237106 - In Vitro Maturation (IVM) for Polycystic Ovary Syndrome (PCOS) N/A
Completed NCT01185704 - Analysis of Two Therapeutic With Cetrotide® in Polycystic Ovarian (PCO) Women in Assisted Reproductive Technology (ART) Phase 3
Recruiting NCT04029805 - Evaluation of a Combination of a Plant Extract and a Probiotic on Glucidic Metabolism in Women With PCOS and High Insulin Levels Phase 1/Phase 2
Completed NCT01675843 - Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome Phase 4
Completed NCT01577017 - The Effects of Letrozole And Clomiphene Citrate For Induction of Ovulation In Polycystic Ovarian Syndrome(PCOS) Phase 3
Completed NCT00478504 - Letrozole Versus Clomifene Citrate for Ovulation Induction Phase 4
Completed NCT05215223 - Effect of Whole Body Vibration on Insulin Resistance in Females With Polycystic Ovarian Syndrome N/A
Completed NCT03358199 - LOD Before IVF/ICSI in PCOS Patients With High AMH N/A
Completed NCT02436226 - Use of Low Dose of HCG During Ovulation Induction With CC in Women With CC Resistant PCOS Phase 4
Recruiting NCT02084940 - Long Acting GnRH Antagonist in PCOS Women Undergoing IVF N/A