Clinical Trials Logo
  1. Home
  2. Pneumonia, Viral
  3. NCT04786301

Severe Acute Respiratory Infection - Preparedness (COVID-19 and Influenza) — SARI-PREP  

Pneumonia, Viral Clinical Trial

Official title:
Severe Acute Respiratory Infection - Preparedness

Clinical Trial Summary

Severe Acute Respiratory Infection (SARI) is defined by the World Health Organization (WHO) as acute respiratory infection with a history of fever ≥38°C and cough for less than 10 days duration that requires hospital admission. SARI-PREP is a multi-center consortium funded by the CDC Foundation being assembled with the goal of providing the infrastructure to rapidly collect prospective data on clinical risks and outcomes, hospital-level stress, and biologic specimens that will aid in the rapid development of diagnostic and treatment approaches. A current example of a form of SARI to be targeted by SARI-PREP is COVID-19 the acute respiratory infectious disease caused by SARS-CoV-2 infection. COVID-19 has a broad set of manifestations and severity with a subset of affected patients developing severe disease leading to respiratory failure and other forms of organ dysfunction. As with many outbreaks of novel viral pathogens causing SARI there was no efficacious therapeutic intervention at the beginning of the COVID-19 pandemic. Furthermore, while there is emerging knowledge of clinical risks for severe COVID-19, there remains a paucity of information about the viral dynamics and host responses that might indicate a patient is at high risk for poor outcomes. The COVID-19 pandemic will be the initial target of the SARI-PREP consortium with the overall goal of developing a multi-institutional collaborative network of Acute Care Hospitals that will rapidly enroll, sample, and follow patients admitted with severe COVID-19 and to develop research protocols to rapidly determine demographic, clinical, host molecular, virologic, and institutional correlates of outcome. Overall, the information gained from this effort will help to rapidly inform and improve clinical management of epidemic/pandemic SARI patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04786301
Study type Observational
Source University of Washington
Contact Nikki Dodd
Phone 206-221-0523
Email doddn@uw.edu
Status Recruiting
Phase
Start date April 30, 2020
Completion date March 2022
View Details
See also
  Status Clinical Trial Phase
Completed NCT04517123 - Prone Position and Respiratory Outcomes in Non-Intubated COVID-19 PatiEnts The "PRONE" Study N/A
Completed NCT04435327 - Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19)
Completed NCT01271842 - Long-term Outcome and Lung Capacity in Survivors of ARDS Due to Influenza A (H1N1) v2009 The RESPIFLU Study N/A
Completed NCT04724538 - Inhalation Low Dose Radionuclide Therapy in Treatment COVID-19 Phase 1/Phase 2
Recruiting NCT04414293 - Low Dose Pulmonary Irradiation in Patients With COVID-19 Infection of Bad Prognosis N/A
Completed NCT04047719 - Pneumonia in the ImmunoCompromised - Use of the Karius Test for the Detection of Undiagnosed Pathogens
Recruiting NCT04528888 - Steroids and Unfractionated Heparin in Critically Ill Patients With Pneumonia From COVID-19 Infection Phase 3
Completed NCT04606407 - Inhaled NO for the Treatment of Viral Pneumonia in Adults N/A
Terminated NCT04619693 - Biomarkers for Dexamethasone Response in Sars-Cov-2 / COVID-19 Pneumonia
Recruiting NCT05077917 - Cromolyn Sodium for Treatment of COVID-19 Pneumonia Phase 3
Withdrawn NCT04381923 - COVIDNOCHE Trial (HFNO Versus CPAP Helmet) in COVID-19 Pneumonia N/A
Recruiting NCT05976581 - Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients N/A
Active, not recruiting NCT04381364 - Inhalation of Ciclesonide for Patients With COVID-19: A Randomised Open Treatment Study (HALT COVID-19) Phase 2
Completed NCT04422613 - Characterization of Persistent Pulmonary Abnormalities Following COVID-19 Pneumonia N/A
Completed NCT04479540 - Assessment of the Risk of Pulmonary Embolism and Coagulation Profile in Patients With COVID-19 Lung Disease N/A
Recruiting NCT04474340 - COVID-19 Convalescent Plasma Treatment in SARS-CoV-2 Infected Patients Phase 1
Completed NCT04424836 - HFNC Treatment in COVID-19 Pneumonia
Active, not recruiting NCT04365101 - Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19 Phase 1/Phase 2
Completed NCT04387799 - Determinants of COVID-19 Pneumonia (MC-19)
Completed NCT04382547 - Treatment of Covid-19 Associated Pneumonia With Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells Phase 1/Phase 2