Pleural Effusion, Malignant Clinical Trial
Official title:
Creation of a Pleural Carcinomatosis Tissue Bank
Malignant pleural effusion is a common evolution of various cancers and is associated with poor prognosis and quality of life. About 28% of patients with primary malignancy will develop pleural metastasis. Malignant pleural effusion mostly occurs in lung, breast, ovarian and gastric cancers. Median survival ranges from 3 to 13 months according to primary malignancy. Currently, the therapeutic approach is mainly palliative with videothoracoscopic talc pleurodesis or indwelling pleural catheters insertion eventually associated with systemic chemotherapy if patient's general condition allows. In a early-disseminated tumor cells profile, metastatic cells can accumulate alterations at a distant site and have a different profil from the original tumor cells. Metastatic cells can also accumulate alterations in the course if systemic treatments. Consequently, they may respond differently to drugs. Recently, EGFR mutations and ALK status discordance between primary tumors and pleural metastases have been demonstrated in a significant portion of lung adenocarcinomas. These studies, realized on malignant pleural effusion isolated cells, enabled us to hypothesize a possible intratumoral heterogeneity within pleural metastases, but no study has been carried out on pleural tissue. Our aim is to create a biocollection with tissues from pleural carcinomatosis in order to subsequently allow multiomics and bioinformatics analyzes and to characterize a possible intratumoral heterogeneity in pleural metastasis.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05693727 -
Cancer Ratio,Pleural Fluid Adenosine Deaminase,Lactate Dehydrogenase, interferonY, Tumor Necrosis Factor,and Interleukins{2,12,18}for Differentiation Between Malignant and Non Malignant Pleural Effusion
|
||
| Recruiting |
NCT05910112 -
Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention
|
||
| Completed |
NCT03270215 -
The Added Value of CT Scanning in Patients With an Unilateral Pleural Effusion
|
||
| Completed |
NCT03272997 -
The Value of PET-CT in Pleural Effusions
|
||
| Completed |
NCT00099541 -
Non-small Cell Lung Cancer Registry
|
Phase 4 | |
| Recruiting |
NCT05278975 -
Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma
|
Phase 1/Phase 2 | |
| Recruiting |
NCT02407912 -
Cisplatin for Malignant Pleural Effusion in Patients With Non-small-cell Lung Cancer
|
N/A | |
| Terminated |
NCT00316134 -
Multiple Biomarkers in Undiagnosed Pleural Effusion
|
N/A | |
| Not yet recruiting |
NCT06275178 -
Medical Thoracoscopy for Diagnosing Unexplained Pleural Effusion: a National Multicenter Retrospective Study
|
||
| Recruiting |
NCT04684459 -
Dual-targeting HER2 and PD-L1 CAR-T for Cancers With Pleural or Peritoneal Metastasis
|
Early Phase 1 | |
| Recruiting |
NCT04670562 -
Longitudinal Follow up of Patients With Pleural Effusion
|
||
| Not yet recruiting |
NCT02805062 -
Manometry vs Clinical Assessment in the Detection of Trapped Lung in Patients With Suspected Pleural Malignancy
|
N/A | |
| Completed |
NCT03276715 -
Prognostic Factors on Malignant Pleural Effusion
|
||
| Completed |
NCT03394105 -
Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer
|
Phase 2 | |
| Recruiting |
NCT05461430 -
Mass Response of Tumor Cells as a Biomarker for Rapid Therapy Guidance (TraveraRTGx)
|
||
| Terminated |
NCT02702700 -
Photo-induction as a Means to Improve Cisplatin Delivery to Pleural Malignancies
|
Phase 1 | |
| Recruiting |
NCT02045121 -
Multicentre Study Comparing Indwelling Pleural Catheter With Talc Pleurodesis for Malignant Pleural Effusion Management
|
N/A | |
| Completed |
NCT01670786 -
Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion
|
Phase 4 | |
| Active, not recruiting |
NCT05077111 -
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
|
Phase 4 | |
| Not yet recruiting |
NCT03781908 -
Management of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis
|
Phase 1/Phase 2 |