Pleural Effusion, Malignant Clinical Trial
Official title:
Management Of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis
The primary goal of this study is to compare well-defined pleural effusion management success outcomes in patients with malignant or paramalignant pleural effusions who were treated with Indwelling pleural catheter insertion compared with those treated with siver nitrate pleurodesis. It is also to demonstrate the effectiveness of silver nitrate pleurodesis. It is also important to evaluate frequent adverse events of silver nitrate pleurodesis in patients with malignant pleural effusion
Dyspnea is present in 50% of patients with malignant pleural effusion and quality of life is
significantly impaired.
Chemical pleurodesis using various sclerosing agents is accepted as a palliative therapy for
patients with recurrent, symptomatic, and malignant pleural effusions.
Silver nitrate solution (SNS) is a valid sclerosing agent that induce a caustic injury to the
mesothelium that results in an effective pleurodesis.
However, various clinical parameters and biochemical factors affect the success of
pleurodesis in symptomatic patients with MPE: symptoms and performance status of the patient,
daily fluid drainage, primary tumour, and mainly lung reexpansion following pleural fluid
evacuation.
The pleural injectate consists of 50 mL 0.5% SNS with 10mL of lidocaine (25mg/5mL).
An alternative treatment is intermittent or continuous drainage of the pleural fluid with a
chronic indwelling pleural catheter.
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