Pleural Effusion Clinical Trial
Official title:
Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy For Diagnosis of Patients With Pleural Effusions: A Randomized Control Trial
The aim of this study is to compare the rigid thoracoscopy with CT-guided pleural needle biopsy by the diagnostic efficacy and safety in patients with pleural effusion.
Pleural needle biopsy with Abrams needle, which can be performed by all chest physicians, is
a simple, safe and cheap method of obtaining tissue from pleura, but its diagnostic rate is
between 7 % -72 %, ~ 50 %. Problems for Abrams needle are scattered tumoral involvement on
pleura, blind performance, small tissue sampling, to tend to early and dense fibrosis and
usually involvement of lower pleural surface and diaphragmatic pleura.
Pleural needle biopsy with Abrams' needle, which can be performed by all chest physicians,
if done with image guided and if this increase the diagnosis rate, the number of second
procedure which is more expensive and hard will decrease.
The study aims the comparison of rigid thoracoscopy with CT-guided pleural needle biopsy by
the diagnostic efficacy and safety in patients with pleural effusion.
It has been planned that a total of 120 patients accepted to the study who have pleural
effusion at plain chest roentgenogram. All patients are being randomized after underwent
contrast-enhanced CT. Undiagnosed patients of biopsy group are performed thoracoscopy and
undiagnosed patients of thoracoscopy group followed up.
Two groups will compare by age, sex, Karnofsky performance status (KPS), diagnosis and
complication rate.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Primary Purpose: Diagnostic
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