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Pleural Diseases clinical trials

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NCT ID: NCT06313632 Recruiting - Postoperative Pain Clinical Trials

Erector Spinae Plane Block With Bupivacaine for Medical Thoracoscopy

Start date: March 13, 2024
Phase: Phase 3
Study type: Interventional

PlAcebo versus erector spINae pLane block for mEdical ThoracoScopy Study (PAINLESS). This is a prospective triple-blind, randomized controlled trial that evaluates the efficacy of erector spinae plane block (ESPB) with Bupivacaine in reducing pain after medical thoracoscopy (MT) in addition to monitored anesthesia care vs monitored anesthesia care alone.

NCT ID: NCT06226909 Recruiting - Pleural Diseases Clinical Trials

The Efficacy of Shear-wave Elastography-guided Biopsy for Diagnosis in Pleural Disease

Start date: January 15, 2024
Phase: N/A
Study type: Interventional

To investigate the information from shear-wave elastography on pleural tissues will improve the diagnosis of pleural diseases, as to increase the diagnostic yield in ultrasound-guided transthoracic pleura biopsy.

NCT ID: NCT06180603 Recruiting - Heart Failure Clinical Trials

Strategy for Prompt and Effective Thoracentesis in the Emergency Department

SPEEDTAP
Start date: January 15, 2024
Phase: N/A
Study type: Interventional

The SPEEDTAP-trial is a prospective, randomised, investigator-initiated, multicenter, clinical superior trial investigating two thoracentesis methods in four emergency departments (ED) in Central Denmark Region. Patients are randomised to either manual fluid removal in the ED or passively fluid drainage using gravity in the radiology department (standard of care). Primary outcome: time from clinical indication to complete drainage and 188 patients will be included. Key secondary outcomes include length of stay, ED admission to ED discharge and safety end-points.

NCT ID: NCT06066398 Not yet recruiting - Clinical trials for Disorder of Pleura and Pleural Cavity

Thoracoscopic Pleural Lavage and Brushing in Undiagnosed Pleural Effusion

Start date: October 1, 2023
Phase: N/A
Study type: Interventional

1. To evaluate the diagnostic yield and safety of thoracoscopic pleural lavage and pleural brushing in cases of undiagnosed exudative pleural effusion.

NCT ID: NCT05910112 Recruiting - Pleural Effusion Clinical Trials

Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention

PROSPECT
Start date: September 1, 2020
Phase:
Study type: Observational

The PROSPECT study aims to look at the number of problems or side effects which occur after patients have had a procedure completed to remove fluid or air from the space between the lung and the chest wall. Other information will also be collected to see whether anything else affects which patients have problems after the procedure such as bleeding or infection. This study will also investigate whether it is possible to find out which patients are likely to feel a lot better after the procedure. Not all patients feel significantly better but it is not clear why this is. There are a number of different reasons patients may not feel better, for example if the lung is not able to fully re-expand. The study aims to look at whether it is possible to predict these problems before the procedure using ultrasound. If it is possible to find the answers to some of these questions it might be possible to prevent patients undergoing treatments which are not likely to benefit them. The study will use information already collected as part of clinical care, as well as questionnaires from patients receiving care at a variety of centres. The different features of these centres will also be considered in analysis.

NCT ID: NCT05906823 Completed - Pleural Diseases Clinical Trials

Analysis of Metabonomics for Pleural Effusion

Start date: January 1, 2016
Phase:
Study type: Observational

This is a multicenter retrospective study that collected diagnostic information of patients with pleural effusion. The overall survival (OS) time of malignant patients was followed up, defined as the time from diagnosis to death. Clinical data and residual pleural effusion specimens were collected from patients. Metabonomics was utilized to differentiate between benign and malignant pleural effusion and to evaluate the prognosis of lung cancer patients with malignant pleural effusion.

NCT ID: NCT05428891 Completed - Clinical trials for Diagnosis of Pleural Diseases

Image-guided Pleural Biopsy or Medical Thoracosocopy in Diagnosis of Pleural Disease

Start date: April 30, 2017
Phase: N/A
Study type: Interventional

Pleural diseases can occur due to numerous pathological conditions. The increasing prevalence of etiologic causes and aging population worldwide will make pleural diseases a growing problem in the coming years. As a result of this increase, the need for diagnostic investigations is also increasing. In recent years, the use of image-guided needle biopsies under ultrasound (US) or computed tomography (CT) and the increasing use of medical thoracoscopy (MT) have significantly increased the accuracy of diagnosis of pleural disease. There is not yet a generally accepted algorithm for invasive diagnosis of pleural disease, widely used in clinics, that determines which method should be used in which patient. It would be necessary and valuable to develop an algorithm based on imaging findings in particular to improve the diagnostic accuracy, safety, and cost of the procedure. The investigators aimed to test the algorithm in an interventional study to increase the level of evidence in this study.

NCT ID: NCT05243316 Completed - Pneumothorax Clinical Trials

Risk of Pneumothorax With and Without Chest Tube Clamping in Patients With Pleural Pathology

Start date: December 22, 2021
Phase: N/A
Study type: Interventional

Through this randomized controlled clinical trial, we aim to identify whether there is a difference in the incidence of 24 hour pneumothorax after chest tube removal, in two blindly randomized groups of patients: The first group with chest tube clamping 6 hours prior to removal, and the second group there will be no chest tube clamping. The data will be prospectively collected from patient records from the National Institute of Respiratory Diseases Ismael Cosío Villegas.

NCT ID: NCT05077111 Active, not recruiting - Clinical trials for Pulmonary Atelectasis

A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia

VATS
Start date: January 15, 2020
Phase: Phase 4
Study type: Interventional

Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including avoidance of airway trauma and ventilator dependence associated with endotracheal intubation, besides promoting enhanced recovery after surgery and shorter mean hospital stay.

NCT ID: NCT04836429 Recruiting - Clinical trials for Lung Non-Small Cell Carcinoma

Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease

Start date: March 10, 2022
Phase: Phase 1
Study type: Interventional

This phase I trial evaluates the side effects of intraoperative photodynamic therapy with porfimer sodium in enhancing the response to immunotherapy with an immune checkpoint inhibitor drug in patients with non-small cell lung cancer with pleural disease. Photodynamic therapy is a technique that that works by combining a photosensitizing agent (porfimer sodium in this trial) and an intense light source to kill tumor cells. Photodynamic therapy may decrease the patients' symptoms and improve their quality of life.