Peutz-Jeghers Syndrome Clinical Trial
Official title:
Poorly Differentiated Adenocarcinoma of the Jejunum in a Patient With Peutz-Jeghers Syndrome: A Case Report
Our study is a case report of one of the rarest risk factor, Peutz-Jeghers syndrome, of small bowel malignancy detected in a patient with poorly differentiated adenocarcinoma of small bowel(jejunum)
Case presentation: A 25-year-old male patient presented to the emergency department with generalized peritonitis caused by a perforated jejunal mass. The patient underwent an emergency exploratory laparotomy. There was 800 ml of thin pus in the peritoneal cavity and 5 cm by 6 cm perforated mass over the jejunum, 30cm from the ligament of the treitz, which extends to the mesentery. Palpable jejunal mesenteric lymphadenopathies were found. There were palpable intraluminal polyps with an inverted serosal surface for some of them, which were identified as 10cm proximal and 20cm distal to the mass. The pus was sucked out, and the mass was resected with its mesenteric lymph nodes and segments containing polyps, a total of 40cm of jejunum. Subsequently, end-to-end hand-sewn anastomosis was performed, and the abdomen was closed. The histopathology report showed poorly differentiated adenocarcinoma, stage IIIC (PT3, PN2), and Peutz-Jeghers polyps, suggesting Peutz-Jeghers syndrome. Lympho-vascular invasion was also noted. The tumor has affected seven of the 12 lymph nodes that have been identified. After 6weeks of uneventful follow-up at the surgical referral clinic, the patient was referred to the oncology department for adjuvant chemotherapy. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03781050 -
Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome
|
Phase 4 | |
| Recruiting |
NCT05692596 -
The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics
|
||
| Withdrawn |
NCT01178151 -
Study of Everolimus in the Treatment of Advanced Malignancies in Patients With Peutz-Jeghers Syndrome
|
Phase 2 | |
| Terminated |
NCT00811590 -
Pilot Study of mTOR Inhibitor Therapy in Peutz-Jeghers Syndrome
|
Phase 2 | |
| Recruiting |
NCT03806075 -
Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome
|
N/A | |
| Recruiting |
NCT06163365 -
Inherited Cancer Early Diagnosis (ICED) Study
|
||
| Completed |
NCT00438906 -
Cancer of the Pancreas Screening Study (CAPS 3)
|
||
| Completed |
NCT00001452 -
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
|
||
| Not yet recruiting |
NCT06001476 -
Cold Snare Polypectomy for Small Bowel Polyps in Patients With Peutz-Jeghers Syndrome
|
Phase 4 | |
| Recruiting |
NCT04095195 -
Registry of Subjects at Risk of Pancreatic Cancer
|
||
| Recruiting |
NCT03050268 -
Familial Investigations of Childhood Cancer Predisposition
|
||
| Completed |
NCT00633607 -
Hereditary Colorectal and Associated Tumor Registry Study
|
N/A |