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Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome

Peutz-Jeghers Syndrome Clinical Trial

Official title:
Molecular Typing and Precise Prevention and Treatment of Peutz-Jeghers Syndrome

Clinical Trial Summary

The mutation of STK11 has been regcognized to be the major cause of Peutz-Jeghers syndrome (PJS).The aim of this study was to confirm the mutation rate of gene associated with gastrointestinal malignancies,including STK11, APC,PMS1,et al. Furtherly, the investigators analyze the association of STK11 with gut microbiota.

Clinical Trial Description

All patients diagnosed as PJS were enrolled and accepted second generation gene sequencing with their blood specimens. Then all patients allocated into gene mutation group and no gene mutation group according to if the cases accompany with gene mutation of STK11.Also, health persons were enrolled and a case controlled study will be carried out.All patients and health persons accepted 16s rRNA sequencing with their feces specimens. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03806075
Study type Interventional
Source Changhai Hospital
Contact Yuxin Wang, Ph.D.
Phone 86-18721819083
Email 18721819083@163.com
Status Recruiting
Phase N/A
Start date March 1, 2018
Completion date September 1, 2021
View Details
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