Peutz-Jeghers Syndrome Clinical Trial
Official title:
Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome
A prospective non-randomized open label single arm clinical trial to examine the efficacy and safety of sirolimus in patients with Peutz-Jeghers Syndrome.
PJS (Peutz-Jeghers Syndrome) is mostly caused by mutations in Lkb1 gene, which leads to an increased activity of mTOR pathway, thus making mTOR inhibitor (sirolimus) a promising candidate in treatment and prevention of PJS. The efficacy of sirolimus (rapamycin) on PJS has been demonstrated in mouse model, but no clinical trials have been reported. Our study was designed as a prospective non-randomized open label single arm clinical trial to examine its efficacy and safety. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05692596 -
The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics
|
||
Withdrawn |
NCT01178151 -
Study of Everolimus in the Treatment of Advanced Malignancies in Patients With Peutz-Jeghers Syndrome
|
Phase 2 | |
Terminated |
NCT00811590 -
Pilot Study of mTOR Inhibitor Therapy in Peutz-Jeghers Syndrome
|
Phase 2 | |
Recruiting |
NCT03806075 -
Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome
|
N/A | |
Recruiting |
NCT06163365 -
Inherited Cancer Early Diagnosis (ICED) Study
|
||
Completed |
NCT06242457 -
Poorly Differentiated Adenocarcinoma of the Jejunum in a Patient With Peutz-Jeghers Syndrome: A Case Report
|
||
Completed |
NCT00438906 -
Cancer of the Pancreas Screening Study (CAPS 3)
|
||
Completed |
NCT00001452 -
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
|
||
Not yet recruiting |
NCT06001476 -
Cold Snare Polypectomy for Small Bowel Polyps in Patients With Peutz-Jeghers Syndrome
|
Phase 4 | |
Recruiting |
NCT04095195 -
Registry of Subjects at Risk of Pancreatic Cancer
|
||
Recruiting |
NCT03050268 -
Familial Investigations of Childhood Cancer Predisposition
|
||
Completed |
NCT00633607 -
Hereditary Colorectal and Associated Tumor Registry Study
|
N/A |