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Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2) In Gingival Recession Defects

Periodontitis Clinical Trial

Official title:
Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2) In Absorbable Collagen Membrane With Coronally Advanced Flap In Class I And II Gingival Recession Defects -A Randomized Control Trial

Clinical Trial Summary

This study was a single-arm trial to obtain preliminary data on the efficacy of collagen membranes impregnated with recombinant human fibroblast growth factor (rhFGF-2) in the treatment of Miller's class I and class II gingival recessions.

Clinical Trial Description

Soft tissues can be regenerated to cover root exposure and a thin biotype can be converted into a thick biotype by using recombinant human growth factor technology. A recent review stated that growth factors could enhance soft tissue regeneration which includes restoration of mucogingival architecture and regeneration of periodontal hard and soft tissues including bone, cementum and periodontal ligament fibers. Fibroblast growth factor-2 (FGF-2), a heparin-binding cytokine with strong angiogenic activity stimulates the proliferation of undifferentiated mesenchymal cells. These functions can be applied in mucogingival surgery as FGF-2 promotes bone and cementum formation and exhibits an increased potential to promote periodontal regeneration in recession defects. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04361630
Study type Interventional
Source SVS Institute of Dental Sciences
Contact
Status Completed
Phase Early Phase 1
Start date May 1, 2019
Completion date December 1, 2019
View Details
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