Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities

Periodontitis Clinical Trial

Official title:

Periodontal-, Cardiovascular- and Aneurysmal Diseases.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01358630
• Other study ID #: 08/322b
• Status: Recruiting
• Phase: N/A
• First received: May 19, 2011
• Last updated: May 23, 2011
• Start date: October 2008
• Est. completion date: October 2015

Study information

• Verified date: November 2010
• Source: University of Oslo
• Contact: Ingar Olsen, Prof.PhD.
• Phone: +47-22840350
• Email: ingar.olsen[@]odont.uio.no
• Is FDA regulated: No
• Health authority: Norway: Regional Ethics Commitee
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: October 2015
• Est. primary completion date: March 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,

Exclusion Criteria:

• patients whom undergone antibiotic treatment the past month.

• patients whom undergone periodontal treatment the past 6 months.

• patients with no teeth

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Periodontitis
• Vascular Disease
• Vascular Diseases

Locations

Country	Name	City	State
Norway	Dental and Medical Faculty, University of Oslo	Oslo

Sponsors (2)

Lead Sponsor	Collaborator
University of Oslo	Oslo University Hospital

Country where clinical trial is conducted

Norway,