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NCT00569075 Clinical Trial

Apoptic Biomarkers of Periodontal Disease

Periodontitis Clinical Trial

Official title:
Apoptotic Biomarkers of Periodontal Disease

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00569075
Other study ID # 2004-04
Secondary ID
Status Completed
Phase N/A
First received December 5, 2007
Last updated May 9, 2017
Start date October 2006
Est. completion date October 2009

Study information
Verified date May 2017
Source University of Michigan
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The goal of this study is to facilitate early diagnosis of gum disease. Proteins associated with cell death will be isolated from gum pockets of diseased and healthy patients and evaluated.

Description:

Early detection of the progression of periodontitis is difficult because it typically relies on comparisons of clinical measurements made with a calibrated probe and nonstandardized radiographs over time. Both methods detect periodontal breakdown only after it has occurred. Therefore, considerable emphasis has been placed on identifying more specific and sensitive methods to diagnose and detect periodontal disease progression. The overall goal of this project is to determine whether specific apoptosis-associated proteins, specifically fibronectin (FN) fragments, caspase-3, soluble Fas, and soluble Fas ligand, sampled from gingival crevicular fluid (GCF) can be used as markers for periodontal disease progression.

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date October 2009
Est. primary completion date October 2009
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Adults over age of 18

- Healthy or diagnosis of periodontitis

Exclusion Criteria:

- Active treatment with anti-inflammatory agents such as NSAIDs or steroids and pregnant females

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• collection of gingival crevicular fluid
GCF samples will be collected at 3 month intervals

Locations
Country Name City State
United States Michigan Center for Oral Health Research Ann Arbor Michigan

Sponsors (1)
Lead Sponsor Collaborator
University of Michigan

Country where clinical trial is conducted

United States, 

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