Apoptic Biomarkers of Periodontal Disease

Status Completed

Clinical Trial Summary

The goal of this study is to facilitate early diagnosis of gum disease. Proteins associated with cell death will be isolated from gum pockets of diseased and healthy patients and evaluated.

Clinical Trial Description

Early detection of the progression of periodontitis is difficult because it typically relies on comparisons of clinical measurements made with a calibrated probe and nonstandardized radiographs over time. Both methods detect periodontal breakdown only after it has occurred. Therefore, considerable emphasis has been placed on identifying more specific and sensitive methods to diagnose and detect periodontal disease progression. The overall goal of this project is to determine whether specific apoptosis-associated proteins, specifically fibronectin (FN) fragments, caspase-3, soluble Fas, and soluble Fas ligand, sampled from gingival crevicular fluid (GCF) can be used as markers for periodontal disease progression. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00569075
Study type	Observational
Source	University of Michigan
Contact
Status	Completed
Phase	N/A
Start date	October 2006
Completion date	October 2009

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04712630` - Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft	N/A
Completed	`NCT06127069` - Treatment of Residual Pockets in Periodontal Patients Using an Oscillating Chitosan Device	N/A
Completed	`NCT04964167` - Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis	Phase 4
Completed	`NCT05906797` - Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.	N/A
Recruiting	`NCT03997552` - NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration	N/A
Completed	`NCT05530252` - Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis	Phase 4
Completed	`NCT04881357` - Antiplaque/Antigingivitis Effect of Lacer Oros Integral	N/A
Recruiting	`NCT03790605` - A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis	Phase 3
Enrolling by invitation	`NCT04971174` - Outcomes of Periodontal Regenerative Treatment
Not yet recruiting	`NCT05568290` - Interleukin-38 Levels in Individuals With Periodontitis
Completed	`NCT04383561` - Relationship Between LRG and Periodontal Disease	N/A
Recruiting	`NCT03997578` - Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects	N/A
Completed	`NCT03901066` - Smoking Dependence and Periodontitis
Enrolling by invitation	`NCT04956211` - Periodontal Treatment and Ischemic Stroke	N/A
Recruiting	`NCT05971706` - Ozone Application in Periodontal Treatment	N/A
Recruiting	`NCT06099574` - A Study on the Oral Health Status of Pregnant Women With Gestational Diabetes and Its Correlation With Oral Flora
Completed	`NCT04402996` - Meteorin-like Levels in Individuals With Periodontitis
Active, not recruiting	`NCT05311657` - Oral Health and Severe COPD
Not yet recruiting	`NCT06453278` - (DDS) in India: a Screening Tool to Identify Prediabetes and Undiagnosed Type 2 Diabetes in Dental Settings
Not yet recruiting	`NCT05643287` - The Effect of Time on the Outcome of Periodontal Treatment.	N/A