Salivary Bacterial Profiles in Relation to Periodontal Treatment

Periodontitis Clinical Trial

Official title:

Short and Long Term Alterations of Subgingival and Salivary Microbiota in Relation to Periodontal Treatment

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02913248
• Other study ID #: UCPH_OI_001
• Status: Completed
• Phase: N/A
• First received: September 20, 2016
• Last updated: February 2, 2017
• Start date: October 2016
• Est. completion date: January 2, 2017

Study information

• Verified date: February 2017
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of the present investigation is to record and compare bacterial compositions in subgingival plaque samples and saliva samples in subjects receiving periodontal treatment. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to periodontal treatment.

Description:

In this study we plan to enroll 35 subjects with manifest periodontitis, which will be treated according to national and international guidelines. Clinical registration and collection of subgingival plaque samples and saliva samples will be performed at baseline and 2, 6 and 12 weeks after treatment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: January 2, 2017
• Est. primary completion date: January 2, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 99 Years

Eligibility

Inclusion Criteria:

• Manifest chronic periodontitis according to international classification

Exclusion Criteria:

• Other treatment requiring oral conditions

• Systemic antibiotics within the latest 6 months

• Systemic diseases and medications with known associations to periodontitis

• Pregnancy and breastfeeding

Related Conditions & MeSH terms

• Periodontitis

Intervention

Procedure:
• Conventional periodontal treatment
Non-surgical periodontal treatment including thorough instruction in self-performed oral hygiene

Locations

Country	Name	City	State
Denmark	University of Copenhagen, Department of Odontology	Copenhagen

Sponsors (3)

Lead Sponsor	Collaborator
University of Copenhagen	Rigshospitalet, Denmark, The Forsyth Institute

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in a-diversity in saliva samples collected .	Comparison of a-diversity in saliva samples collected before periodontal treatment and 12 weeks after treatment	Baseline and 12 weeks
Secondary	Specis specific changes in saliva samples collected	Comparison of relative abundance of bacterial species in saliva samples collected before periodontal treatment to samples collected 12 weeks after treatment	Baseline and 12 weeks