Periodontal Inflammation Clinical Trial
Official title:
Role of TLR2 and TLR4 in Stage 2 Periodontitis Patients With and Without Type 2 Diabetes
In Health, mucosal inflammation is prevented by TLR (Toll like receptors) that interact with Specific MAMP (microbe associated molecular pattern). Currently about 13TLRs have been identified. Among them, TLR2 and 4 recognize most organisms . Periodontal disease is mixed infection resulting due to dysbiosis . When aggravated by systemic disease the role of TLRs is detrimental for the overall state of periodontal apparatus. Type 2 diabetes is one of the systemic disease which is seen a risk factor if uncontrolled can exaggerate the titer of TLR2 and TLR4 biomarkers . Various studies have been evaluated to determine the role of TLRs in autoimmune and periodontal conditions. The purpose of this study is to determine if both TLR2 and TLR4 play equal roles in periodontal disease and in cases where periodontal disease is complicated by the presence of systemic disease. Individual role of TLR2 and TLR4 in active disease will help determine treatment strategies and will also be able to predict potential biomarker in disease.
In Health, mucosal inflammation is prevented by TLR (Toll like receptors) that interact with
Specific MAMP (microbe associated molecular pattern). Currently about 13TLRs have been
identified. Among them, TLR2 and 4 recognize most organisms. Periodontal disease is mixed
infection resulting due to dysbiosis. When aggravated by systemic disease the role of TLRs is
detrimental for the overall state of periodontal apparatus. Type 2 diabetes is one of the
systemic disease which is seen a risk factor if uncontrolled can exaggerate the titer of TLR2
and TLR4 biomarkers. Various studies have been evaluated to determine the role of TLRs in
autoimmune and periodontal conditions. The purpose of this study is to determine if both TLR2
and TLR4 play equal roles in periodontal disease and in cases where periodontal disease is
complicated by the presence of systemic disease. Individual role of TLR2 and TLR4 in active
disease will help determine treatment strategies and will also be able to predict potential
biomarker in disease.
Periodontal diseases are classified according to the American academy of periodontology as
stage 1, 2, 3&4 according to severity and extent of the disease progression.
Stage 2 periodontitis was selected as it is considered as an intermediary, because
CAL(clinical attachment loss was standardized at 3-4mm,this could reflect the progression of
disease and its impact from a horizontal bone loss to a more oblique one, if in case the
dysbiosis persists.
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