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NCT03639376 Clinical Trial

Passive Smoking and LL-37 in Children

Periodontal Health Clinical Trial

Official title:
Salivary LL-37 and Periodontal Health in Children Exposed to Passive Smoking

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03639376
Other study ID # 2016/140
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 2016
Est. completion date June 2018

Study information
Verified date August 2018
Source Kirikkale University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study investigates the salivary LL-37 in passive smoking-exposed and unexposed children and the association between salivary LL-37 levels and periodontal clinical parameters in these children.Unstimulated salivary samples were collected from 180 children (90 passive smoking-exposed and 90 passive smoking-unexposed)

Description:

Diverse mechanisms conduce to the detrimental periodontal effects of passive smoking, including alteration of both microbial and host response factors.

Antimicrobial peptides are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the oral gingival epithelium and in the transition to acquired immunity.

LL-37 has a wide antimicrobial activity against both cariogenic and periopathogenic bacteria and its role in maintaining oral health has recently been stated

Recruitment information / eligibility
Status Completed
Enrollment 180
Est. completion date June 2018
Est. primary completion date April 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 6 Years to 12 Years
Eligibility Inclusion Criteria:

- Systemically healthy children

Exclusion Criteria:

- Any medications known to affect defense system and periodontium

- The presence of orthodontic / intraoral appliance

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Kirikkale University

Outcome
Type Measure Description Time frame Safety issue
Primary Antimicrobial Peptide LL-37 (pg/mL) In the first 18 months of study
Secondary Passive smoking measurement Cotinine (ng/mL) In the first 18 months of study
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