Systemic Amoxicillin Plus Metronidazole in Peri-implantitis Treatment

Status Completed

Clinical Trial Summary

The primary objective of this controlled clinical trial is to evaluate the clinical effect of systemic amoxicillin plus metronidazole therapy in conjunction with initial non-surgical treatment of peri-implantitis. The secondary objective is to assess the microbiological effectiveness of this peri-implantitis treatment approach. The present study is a single-blind, randomized controlled clinical trial. Adult patients with at least one endosseous implant in the oral cavity with clinical and radiographical evidence of periimplantitis will be included in this study. Patients with implants affected by peri-implantitis will receive initial periodontal treatment existing of oral hygiene instructions and mechanical cleansing of both implants and remaining dentition. Immediately after initial periodontal therapy patients will be instructed to rinse their mouth with 0.12% chlorhexidine + 0.05% cetylpyridinium chloride without alcohol twice daily during 30 seconds for 2 weeks. Additionally patients will receive a recipe for medication consisting of 500 mg amoxicillin and 500 mg metronidazole to be taken every 8 hours for the following 7 days or no recipe. The main study parameter is the mean peri-implant bleeding score.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04149327
Study type	Interventional
Source	University Medical Center Groningen
Contact
Status	Completed
Phase	Phase 4
Start date	August 1, 2012
Completion date	December 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04712630` - Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft	N/A
Recruiting	`NCT03997552` - NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration	N/A
Completed	`NCT04478864` - Knowledge, Practice and State of Periodontal Health
Completed	`NCT03507868` - YKL-40 and IL-6 Levels in Periodontal Disease
Completed	`NCT05720481` - Impact of Periodontal Treatment on Growth Differentiation Factor-15 Levels	N/A
Recruiting	`NCT06052150` - Oral Health In Cirrhosis of the Liver (ORACLE)
Recruiting	`NCT06025955` - Evaluation of Outcomes of Minimally Invasive Non- Surgical Versus Surgical Therapy in Furcation Involvement.	N/A
Recruiting	`NCT03510702` - SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
Completed	`NCT05631600` - Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study	Phase 2/Phase 3
Active, not recruiting	`NCT05068778` - Development of an AI App to Improve Compliance in Periodontal Maintenance Patients
Not yet recruiting	`NCT05178563` - Mechanisms of Acute Inflammation Following Periodontal Treatment	N/A
Recruiting	`NCT06086821` - Clinical Relevance of Different Time of Periodontal Re-evaluation	N/A
Recruiting	`NCT06224699` - Toothpaste With Sodium Carbonate in Patients With Gingivitis	N/A
Not yet recruiting	`NCT05721313` - Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study	N/A
Completed	`NCT06306937` - Serum Levels of Vitamin D and IL8 in Patients With Periodontitis
Completed	`NCT06040944` - Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients
Recruiting	`NCT04669717` - Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies	Phase 4
Completed	`NCT05576142` - Oral Findings in Pediatric Patients With Allergic Rhinitis and/or Asthma
Not yet recruiting	`NCT03588507` - Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects	N/A
Completed	`NCT04017078` - Assessment of Carotid Artery Calcifications