Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease

Periodontal Diseases Clinical Trial

Official title:

Evaluation of Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease and Healthy Implants

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03527901
• Other study ID #: BAP-17/1
• Status: Completed
• Start date: March 1, 2015
• Est. completion date: June 1, 2016

Study information

• Verified date: May 2016
• Source: Adnan Menderes University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The aim of this study to evaluate the diagnostic accuracy of a new qualitative aMMP‐8 POC test in different periodontal health and disease and as compared to the established quantitative laboratory method (ELISA)

Description:

MMP-8 has been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. A positive aMMP-8 test could be an early indicator of these excessive and undesired tissue reactions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 103
• Est. completion date: June 1, 2016
• Est. primary completion date: March 1, 2016
• Gender: All
• Age group: 20 Years to 60 Years

Eligibility

Inclusion Criteria:

• Systemically healthy

• Nonsmokers

Exclusion Criteria:

• Participants were not included if they had systemic disease such as diabetes, cardiovascular.

• Participants who took regular medications that could affect of periodontal tissue

• Participants who received antibiotics less than 10 weeks before the study

Related Conditions & MeSH terms

• Gingival Diseases
• Periodontal Diseases

Intervention

Diagnostic Test:
• GCF collection with aMMP-8 chair side test

Other:
• Saliva collection

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Adnan Menderes University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	aMMP-8 levels of GCF	GCF levels measured by IFMA	2 hours
Secondary	Salivary MMP-8 levels	Saliva levels measured by IFMA	2 hours