Antimicrobial Activity of Two Mouthwashes

Status Completed

Clinical Trial Summary

This is a three arm randomized trial. The aim is to evaluate the antimicrobial activity of chlorhexidine and polyhexamethylene biguanide oral antiseptics on the microorganisms of the oral cavity. A total of 30 healthy volunteers will be enrolled and randomly allocated to control group (CG, n=10), which will be instructed to rinse the mouth with 10ml of a sterile saline solution for one minute, to chlorhexidine group (ClG, n=10), which will be instructed to rinse the mouth with 10ml of an 0.12% chlorhexidine solution, for one minute, or to polyhexamethylene biguanide group (PG, n=10), which will be instructed to rinse the mouth with 10ml of an 0.07% polyhexamethylene biguanide solution, for one minute. Samples of saliva will be collected before the mouth wash and after 30, 60 and 180 minutes. Samples will be plated on manitol agar, mitis salivarius agar, EMB agar and Sabouraud agar. Samples will be processed by a blinded microbiologist.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02375178
Study type	Interventional
Source	Universidade do Vale do Sapucai
Contact
Status	Completed
Phase	N/A
Start date	August 2014
Completion date	December 2015

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04712630` - Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft	N/A
Recruiting	`NCT03997552` - NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration	N/A
Completed	`NCT04478864` - Knowledge, Practice and State of Periodontal Health
Completed	`NCT03507868` - YKL-40 and IL-6 Levels in Periodontal Disease
Completed	`NCT05720481` - Impact of Periodontal Treatment on Growth Differentiation Factor-15 Levels	N/A
Recruiting	`NCT06052150` - Oral Health In Cirrhosis of the Liver (ORACLE)
Recruiting	`NCT06025955` - Evaluation of Outcomes of Minimally Invasive Non- Surgical Versus Surgical Therapy in Furcation Involvement.	N/A
Recruiting	`NCT03510702` - SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
Completed	`NCT05631600` - Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study	Phase 2/Phase 3
Active, not recruiting	`NCT05068778` - Development of an AI App to Improve Compliance in Periodontal Maintenance Patients
Not yet recruiting	`NCT05178563` - Mechanisms of Acute Inflammation Following Periodontal Treatment	N/A
Recruiting	`NCT06224699` - Toothpaste With Sodium Carbonate in Patients With Gingivitis	N/A
Recruiting	`NCT06086821` - Clinical Relevance of Different Time of Periodontal Re-evaluation	N/A
Not yet recruiting	`NCT05721313` - Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study	N/A
Completed	`NCT06040944` - Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients
Completed	`NCT06306937` - Serum Levels of Vitamin D and IL8 in Patients With Periodontitis
Recruiting	`NCT04669717` - Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies	Phase 4
Completed	`NCT05576142` - Oral Findings in Pediatric Patients With Allergic Rhinitis and/or Asthma
Completed	`NCT04017078` - Assessment of Carotid Artery Calcifications
Completed	`NCT03694496` - The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong	N/A