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Clinical Trial Summary

To validate a new method for assessing perioperative risk in the cancer patient undergoing major cancer surgery. In this proposed study researchers will: 1. Measure preoperative energy reserve capacity (fitness) 2. Determine if postoperative morbidity is a function of perioperative cardiopulmonary gas exchange metabolism


Clinical Trial Description

Primary Objective: • To characterize the effects of neoadjuvant therapy (chemotherapy, radiation therapy, and/or immunotherapy) on functional capacity in esophageal and lung cancer participants as measured by gas exchange parameters (%predicted AT, %predicted P-VO2, VO2 at AT & peak exercise, oxygen pulse, ΔVO2/ΔWR, ΔVE/ΔVCO2) obtained from CPET before and after neoadjuvant therapy. Secondary Objectives: • To characterize changes in CPET measures in participants treated with chemotherapy, radiation therapy, and/or immunotherapy followed by surgery and correlate these changes with postoperative outcome. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00493688
Study type Observational
Source M.D. Anderson Cancer Center
Contact Anh Q Dang, MD
Phone 713-745-5025
Email adang@mdanderson.org
Status Recruiting
Phase
Start date October 30, 2005
Completion date October 30, 2025

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