Imaging a Cholinergic Biomarker of Cognition in Parkinson's Disease

Status Recruiting

Clinical Trial Summary

This is an imaging study designed to illuminate the function of the cholinergic system and its association with cognitive skills in people with Parkinson's disease. The hypothesis of this study is that there will be an association between cholinergic terminal density, sex hormones, and cognitive functioning. Participants will receive a PET and MRI scan along with a battery of neurocognitive tests at baseline and again at 18 months follow-up. Hormone levels will be measured at baseline.

Clinical Trial Description

This is an imaging study designed to illuminate the functioning of the cholinergic system in people with Parkinson's disease. Some people with Parkinson's disease develop trouble with certain aspects of thinking such as memory. Studies have shown an association between a decline in thinking skills and dysfunction of the cholinergic system. This study will use the novel PET tracer [18F]VAT to provide more specific information about how the cholinergic system works by enabling direct measurement of cholinergic terminal density and projections. The hypothesis of this study is that there will be an association between cholinergic terminal density, sex hormones, and cognitive functioning. This is a longitudinal observational study that involves a screening visit and four study visits over the course of 18 months. The visits consist of neurocognitive assessments and imaging (MRI and PET scans) administered at baseline and at 18 months follow-up. Hormone levels will also be measured at baseline. This study is open to people with Parkinson's disease who have either normal cognition or mild cognitive impairment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05034263
Study type	Observational
Source	Stony Brook University
Contact	Sandra Skinner, PhD
Phone	631-444-7513
Email	sandra.skinner@stonybrookmedicine.edu
Status	Recruiting
Phase
Start date	May 27, 2021
Completion date	May 27, 2024

View Details

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