Parkinson's Disease Clinical Trial
— ATMFOGOfficial title:
A Pilot Study of Atomoxetine for Freezing of Gait in Parkinson's Disease
Verified date | November 2018 |
Source | Medical University of South Carolina |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Subjects are being asked to participate in this study to determine the safety and effectiveness of a drug called atomoxetine in the treatment of freezing of gait for Parkinson's Disease patients. Atomoxetine (ATM) is an approved drug currently on the market for the treatment of attention deficit. It works to increase the amount of norepinephrine (a chemical in the brain that helps keep us awake and alert) in our brain. ATM has not been approved by the Food and Drug Administration (FDA) to be used in the treatment of PD, but has been found to be well tolerated in this patient population.
Status | Completed |
Enrollment | 10 |
Est. completion date | February 2014 |
Est. primary completion date | February 2014 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: 1. Diagnosis of Idiopathic Parkinson's Disease according to UK Brain Bank Criteria, Hoehn and Yahr stage 2-4 2. A positive response to item 14 of the UPDRS, part 2. 3. Age range 18-80 4. Ability to walk a minimum of 20 feet without assistive device and with one observed freezing episode which may be triggered by visual cue 5. Letter of medical clearance by primary care physician dated within preceding 2 months of subject's initial active study visit. 6. Stable on PD medications for = 3 months Exclusion Criteria: 1. Intolerance to drug class 2. Mini-Mental Status Examination <26/30 3. No observable episodes of freezing of gait despite common visual cues 4. Not on stable PD medications for 3 months 5. Subjects who whose gait disturbance is due to other conditions not related to PD or FOG. 6. Current use of monoamine oxidase inhibitor (MAO-I) 7. Hypersensitivity to drug class 8. Narrow angle glaucoma 9. Pheochromocytoma 10. Severe cardiovascular disorders, i.e. patients with pre-existing conditions that would be expected to deteriorate if their heart rate or blood pressure were to increase in a clinically significant manner (e.g. 15-20 mmHg increase in blood pressure or 20 beats per minute in heart rate). 11. Patients with uncontrolled hypertension. 12. Patients with a history of symptomatic tachyarrhythmias. 13. Presence of uncontrolled depression and suicidal ideation. |
Country | Name | City | State |
---|---|---|---|
United States | Medical University of South Carolina | Charleston | South Carolina |
Lead Sponsor | Collaborator |
---|---|
Medical University of South Carolina |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of Participants With Treatment Emergent Adverse Events | Evaluate the safety of Atomoxetine 40mg bid in PD patients with FOG (Freezing of Gait) | week 8 |
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