Parkinson's Disease Clinical Trial
Official title:
Effectiveness of High-frequency Specific Speech Therapy on Verbal Fluency Decline and/ or Verbal Apraxia in Patients With Parkinson's Disease With and Without Deep Brain Stimulation (DBS) - a Randomized Controlled Single-blinded Trial
Due to Parkinson's Disease (PD) speech and language (SL) deficits may occur. Further, the
literature reports that PD patients, who have not undergone deep brain stimulation (DBS),
have deficits regarding voice quality (e.g. loudness and intelligibility of their voice),
while PD patients who have undergone DBS suffer from deficits in word retrieval and speech
apraxia symptoms. To-date, therapeutic approaches focusing specifically on SL deficits
observed in PD-DBS patients are yet to be developed and evaluated.
Therefore, this study investigates the short-and longterm effectiveness of specific and
intensive, high-frequency speech-language therapy in terms of reducing SL-deficits compared
to a nonspecific and non-verbal sham treatment (i.e. a rhythmic balance-movement training
(rBMT)) as well as to a 'no-therapy' condition.
In the course of Parkinson's disease (PD) speech and language (SL) deficits may often emerge.
In addition, severe verbal fluency (VF) decline has been repeatedly observed in the context
of deep brain stimulation (DBS) in PD. Interestingly, while PD non-DBS patients have deficits
with respect to loudness and intelligibility of their voice, PD patients who have undergone
DBS (PD-DBS) suffer rather from difficulties in semantic and phonemic word retrieval, and
from speech apraxia symptoms.
However, to-date and to the best of our knowledge, therapeutic approaches focusing
specifically on SL deficits observed in PD-DBS patients are yet to be developed and evaluated
regarding their effectiveness. Thus, this study investigates the short-and longterm
effectiveness of specific and intensive, high-frequency speech-language therapy in terms of
reducing SL-deficits compared to a nonspecific and non-verbal sham treatment (i.e. a rhythmic
balance-movement training (rBMT)) as well as to a 'no-therapy' condition.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02915848 -
Long-term Stability of LFP Recorded From the STN and the Effects of DBS
|
||
| Recruiting |
NCT03648905 -
Clinical Laboratory Evaluation of Chronic Autonomic Failure
|
||
| Terminated |
NCT02688465 -
Effect of an Apomorphine Pump on the Quality of Sleep in Parkinson's Disease Patients (POMPRENELLE).
|
Phase 4 | |
| Completed |
NCT05040048 -
Taxonomy of Neurodegenerative Diseases : Observational Study in Alzheimer's Disease and Parkinson's Disease
|
||
| Active, not recruiting |
NCT04006210 -
Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
|
Phase 3 | |
| Completed |
NCT02562768 -
A Study of LY3154207 in Healthy Participants and Participants With Parkinson's Disease
|
Phase 1 | |
| Completed |
NCT00105508 -
Sarizotan HC1 in Patients With Parkinson's Disease Suffering From Treatment-associated Dyskinesia
|
Phase 3 | |
| Completed |
NCT00105521 -
Sarizotan in Participants With Parkinson's Disease Suffering From Treatment Associated Dyskinesia
|
Phase 3 | |
| Recruiting |
NCT06002581 -
Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression of Parkinson's Disease
|
N/A | |
| Completed |
NCT02236260 -
Evaluation of the Benefit Provided by Acupuncture During a Surgery of Deep Brain Stimulation
|
N/A | |
| Completed |
NCT00529724 -
Body Weight Gain, Parkinson, Subthalamic Stimulation
|
Phase 2 | |
| Active, not recruiting |
NCT05699460 -
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
|
||
| Completed |
NCT03703570 -
A Study of KW-6356 in Patients With Parkinson's Disease on Treatment With Levodopa-containing Preparations
|
Phase 2 | |
| Completed |
NCT03462680 -
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures
|
N/A | |
| Completed |
NCT02837172 -
Diagnosis of PD and PD Progression Using DWI
|
||
| Not yet recruiting |
NCT04046276 -
Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease
|
N/A | |
| Recruiting |
NCT02952391 -
Assessing Cholinergic Innervation in Parkinson's Disease Using the PET Imaging Marker [18F]Fluoroethoxybenzovesamicol
|
N/A | |
| Active, not recruiting |
NCT02937324 -
The CloudUPDRS Smartphone Software in Parkinson's Study.
|
N/A | |
| Completed |
NCT02939391 -
A Study of KW-6356 in Subjects With Early Parkinson's Disease
|
Phase 2 | |
| Terminated |
NCT02894567 -
Evaluation of Directional Recording and Stimulation Using spiderSTN
|
N/A |