The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients With Parkinson's Disease

Parkinson's Disease Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02037451
• Other study ID #: 102-3809A3
• Status: Recruiting
• Phase: N/A
• First received: January 14, 2014
• Last updated: January 14, 2014
• Start date: August 2013
• Est. completion date: August 2014

Study information

• Verified date: January 2014
• Source: Chang Gung University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Interventional

Clinical Trial Summary

Parkinson's disease (PD) is a progressive degenerative disease of central nervous systems deficit. The clinical symptoms of Parkinson's disease include the following motor tasks: difficult in initiating movement, performing rhythmic movement or serial movement, the ability of learning motor movement is also affected. The primary treatment for Parkinson's disease is medical treatment; surgery is used if in need. Rehabilitation such as physical therapy, which aims to improve patient's quality of life and functions, is a non-invasive treatment and value for PD patients. Auditory cue is a technique that widely applied on training patients with Parkinson's disease, and some researches revealed that auditory cueing could improve motor performance. However, the mechanism under this treatment technique is still unknown.

This study is to investigate the effect of auditory cueing on rhythmic finger movement in patients with Parkinson's disease. To investigate the mechanism under auditory cueing, neurophysiological data such as motor cortex excitability and blood flow in cortical cortex will be obtained by using Transcranial magnetic stimulation (TMS) and near infrared spectroscopy (NIRS).

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 38
• Est. completion date: August 2014
• Est. primary completion date: August 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Clinical diagnosis of Parkinson disease

Exclusion Criteria:

• Clinical diagnosis of other neurological diseases

• Dementia

• Been diagnosed with any mental illness

• History of seizures

• Brain trauma

• Body with a pacemaker or other electrical stimulator

• Pregnancy

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Parkinson Disease
• Parkinson's Disease

Intervention

Procedure:
• rhythmic auditory stimulation
Participants perform the finger tapping at the same time give rhythmic auditory stimulation ,and need to execute tapping with auditory stimulation.

Locations

Country	Name	City	State
Taiwan	Chang Gung University	Taoyuan

Sponsors (1)

Lead Sponsor	Collaborator
Chang Gung University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Finger Tapping	Record pre-test and post-test change.	Baseline,45-60 minutes.	No
Primary	Motor evoked potential	Use single-pulse TMS to assess Motor evoked potential change.	Baseline,45-60 minute	No
Primary	Intracortical inhibition & Intracortical facilitation	Use paired-pulse TMS to record pre-test and post-test change.	Baseline,45-60 minutes	No
Primary	Blood oxygen dependent level	Use Near-infrared spectroscopy to record pre-test, in experiment, and post-test change.	Baseline, in experiment,45-60 minutes	No