Parkinson's Disease Clinical Trial
Official title:
[11C]Donepezil PET For Imaging The Autonomous Nervous System In Parkinsons Disease
AIM: Investigate wether there are differences in the parasympathetic nervous system in
Parkinsons patients compared to controls.
MATERIALS AND METHODS: We use the tracer [11C]donepezil to image the parasympathetic nervous
system. The Investigators will include 20 Parkinsons patients and 20 healthy controls aged
40-80 in our study. The participants will receive a careful medical examination, including a
neurological examination, as part of the inclusion process. The subjects also have an MRI
scan of the brain. Then PET/CT scans with [11C]donepezil are conducted - once for the upper
abdominal region and once for the head region. For evaluating the function of the
parasympathetic nervous system gastric emptying time, heart rate variability and salivary
flow will be measured. These measureless will be correlated to the PET findings.
PERSPECTIVES: The study will potentially result in the development of a PET ligand for
imaging the parasympathetic nervous system. This will have applications for research in
Parkinson's disease, diabetes, heart disease and other disorders, in which the autonomic
nervous system is involved
n/a
Observational Model: Case Control, Time Perspective: Cross-Sectional
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