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Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson's Disease and Tremor

Parkinson's Disease Clinical Trial

Official title:
Randomised Crossover Trial of Deep Brain Stimulation of Differential Posterior Subthalamic Area Regions in Parkinson's Disease and Tremor

Clinical Trial Summary

The posterior subthalamic area holds promise as a target region for deep brain stimulation in tremor and Parkinson's disease. Using the magnetic resonance-directed implantable guide tube surgical technique, subregions of the posterior subthalamic area can be individually targetted on a single electrode lead trajectory. The hypothesis is that the caudal zona incerta may provide improved control of movement disorder symptoms than the more commonly stimulated dorsal zona incerta.

Clinical Trial Description

Randomisation between two treatment locations each programmed up to 3 milliamps in amplitude for 3 months: (1) caudal zona incerta and (2) dorsal zona incerta. This 6-month-long randomised phase is followed by 6 months of unblinded individualised empirically optimised settings programmed by a neurologist. Each of the three treatment periods ends with a full clinical, functional and quality of life assessment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01945567
Study type Interventional
Source The University of Western Australia
Contact
Status Completed
Phase Phase 2
Start date August 2012
Completion date August 30, 2020
View Details
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