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LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease

Parkinson's Disease Clinical Trial

Official title:
LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease

Clinical Trial Summary

This proposal seeks to 1) determine whether there are biomarkers associated with Parkinson's disease (PD) susceptibility and/or progression in exosome-proteomes derived from PD patients versus controls, and 2) to determine if LRRK2 expression and/or phosphorylation are significantly lowered in the exosomes of individuals treated with the potent LRRK2 kinase inhibitor sunitinib (a multi-kinase inhibitor compound), to establish an assay for on-target effects for future LRRK2 inhibitor clinical trials.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01860118
Study type Observational
Source University of Alabama at Birmingham
Contact
Status Completed
Phase
Start date January 2013
Completion date June 21, 2016
View Details
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