Speech Intelligibility of Patients With P D Compared to First Degree Relatives of P D Patients

Parkinson's Disease Clinical Trial

Official title:

Speech Intelligibility of Patients With Parkinsons Disease at Different Stages of the Disease Compared to First Degree Relatives of Parkinson's Disease Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT01776879
• Other study ID #: TASMC-12-TG-0556-CTIL
• Secondary ID: 0556-12
• Status: Not yet recruiting
• Phase: N/A
• First received: November 13, 2012
• Last updated: January 23, 2013
• Start date: February 2013
• Est. completion date: November 2014

Study information

• Verified date: January 2013
• Source: Tel-Aviv Sourasky Medical Center
• Contact: Tanya Gurevich, MD
• Phone: 97236973061
• Email: gurevich[@]tasmc.health.gov.il
• Is FDA regulated: No
• Health authority: Israel: Ethics Commission
• Study type: Observational

Clinical Trial Summary

This study will examine speech intelligibility of early parkinson's disease (PD) patients, early PD patients and first degree relatives. The investigators hypothesis that advanced PD patients will present decreased speech intelligibility more than early PD patients. Speech intelligibility of first degree relatives will be normal.

Description:

in order to achieve the study's goals objective and subjective research tools will be used.

Objective tools include measuring phonation time, diadokokinetic movements of the oral structures and acoustic analysis .

Subjective tools include self reported questionnaires.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: November 2014
• Est. primary completion date: November 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 20 Years to 90 Years

Eligibility

Inclusion Criteria:A

• Advanced PD patients

• Early PD patients

• First degree relatives

Exclusion Criteria:

• Patients with decreased cognitive abilities

• Patients who participate in speech therapy

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Parkinson Disease
• Parkinson's Disease

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Tel-Aviv Sourasky Medical Center

References & Publications (1)

Amir, O., Ashkenazi, O., Leibovitzh, T., Michael, O., Tavor, Y., & Wolf, M. (2006). Applying the Voice Handicap Index (VHI) to Dysphonic and Nondysphonic Hebrew Speakers. Journal of Voice, 318-324. Giladi, N., Treves, T. A., Paleacu, D., Shabtai, H., Orlov, Y., Kandinov, B., Simon, E. S., & Korczyn, A. D. (2000). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695-699 Sapir, S., Raming, L., & Fox, C. (2008) speech and swallowing disorder In Parkinson disease. Speech therapy and rehabilitation. 205-210. Wolters, E. Ch. (2009). Non-motor extranigral signs and symptoms in Parkinson's disease. Parkinsonism and Related Disorders , 6-12. Manor, Y. Giladi, N. Cohen, A. Fliss, D. Cohen. Y. (2007) Validation of a swallowing disturbance questionnaire for detecting dysphagia in patients with Parkinson's disease. Movement Disorders.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximum phonation time	maximum phonation time will be measured after taking few measurements of sentence reading.It is an observational study that aim to collect data during DAY 1 only! day 1 for outcome measure time frames There are not pre/post measurements	DAY 1	No
Secondary	Diadokokinetik (DDK): production time of 10x PATAKA, 7x /P/ and 7x /t/	production time of 10x PATAKA, 7x /P/ and 7x /t/ will be measured during the examination.; It is an observational study that aim to collect data during DAY 1 only! DAY 1 for outcome measure time frames There are not pre/post measurements	DAY 1	No