Parkinson's Disease Clinical Trial
Official title:
Effect of a Structured Physical Activity Program on Sleep Quality and Sleepiness in Parkinson's Disease
The purpose of this study is to examine the ability of a structured physical activity program to improve sleep quality and daytime sleepiness in patients with Parkinson's disease.
Parkinson's disease (PD) is a chronic, progressive, neurodegenerative disease that affects
1% of elderly people. Sleep disturbances affect up to 88% of patients with PD and commonly
include sleep fragmentation and excessive daytime sleepiness (EDS); these symptoms can
significantly impair quality of life. The cause of sleep fragmentation and EDS is likely
multifactorial, including medications, neurodegeneration, primary sleep disorders such as
sleep apnea, and decreased physical activity. Pharmacotherapy in this population is limited
due to side effects and drug-drug interactions.
The goal of this project is to develop non-pharmacologic therapies for impaired sleep
quality and EDS in PD. Sleep disturbances and EDS are common among patients with PD and
negatively affect their quality of life. There is data to support a role for physical
activity in sleep in older adults with and without insomnia. Additionally, increased
physical activity in patients with PD has been associated with improvement in PD motor
symptoms and quality of life. Therefore, the investigators propose to examine the ability of
structured physical activity to improve sleep quality and daytime sleepiness in patients
with PD.
The overall objective of the proposed project is to develop behavioral approaches to improve
sleep quality and daytime function in PD. The investigators propose to examine the effect of
a structured physical activity program and sleep hygiene education on nighttime sleep
quality and EDS in patients with idiopathic PD. There will be two groups: 1) a structured
physical activity program with sleep hygiene education (SPA group), and 2) a control group
receiving only sleep hygiene education (SH group) who will be offered the delayed physical
activity program.
The investigators hypothesize that the structured physical activity program will improve
subjective and objective sleep quality and daytime sleepiness compared to sleep hygiene
education alone.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02915848 -
Long-term Stability of LFP Recorded From the STN and the Effects of DBS
|
||
| Recruiting |
NCT03648905 -
Clinical Laboratory Evaluation of Chronic Autonomic Failure
|
||
| Terminated |
NCT02688465 -
Effect of an Apomorphine Pump on the Quality of Sleep in Parkinson's Disease Patients (POMPRENELLE).
|
Phase 4 | |
| Completed |
NCT05040048 -
Taxonomy of Neurodegenerative Diseases : Observational Study in Alzheimer's Disease and Parkinson's Disease
|
||
| Active, not recruiting |
NCT04006210 -
Efficacy, Safety and Tolerability Study of ND0612 vs. Oral Immediate Release Levodopa/Carbidopa (IR-LD/CD) in Subjects With Parkinson's Disease Experiencing Motor Fluctuations
|
Phase 3 | |
| Completed |
NCT02562768 -
A Study of LY3154207 in Healthy Participants and Participants With Parkinson's Disease
|
Phase 1 | |
| Completed |
NCT00105521 -
Sarizotan in Participants With Parkinson's Disease Suffering From Treatment Associated Dyskinesia
|
Phase 3 | |
| Completed |
NCT00105508 -
Sarizotan HC1 in Patients With Parkinson's Disease Suffering From Treatment-associated Dyskinesia
|
Phase 3 | |
| Recruiting |
NCT06002581 -
Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression of Parkinson's Disease
|
N/A | |
| Completed |
NCT02236260 -
Evaluation of the Benefit Provided by Acupuncture During a Surgery of Deep Brain Stimulation
|
N/A | |
| Completed |
NCT00529724 -
Body Weight Gain, Parkinson, Subthalamic Stimulation
|
Phase 2 | |
| Active, not recruiting |
NCT05699460 -
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
|
||
| Completed |
NCT03703570 -
A Study of KW-6356 in Patients With Parkinson's Disease on Treatment With Levodopa-containing Preparations
|
Phase 2 | |
| Completed |
NCT03462680 -
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures
|
N/A | |
| Completed |
NCT02837172 -
Diagnosis of PD and PD Progression Using DWI
|
||
| Not yet recruiting |
NCT04046276 -
Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease
|
N/A | |
| Recruiting |
NCT02952391 -
Assessing Cholinergic Innervation in Parkinson's Disease Using the PET Imaging Marker [18F]Fluoroethoxybenzovesamicol
|
N/A | |
| Active, not recruiting |
NCT02937324 -
The CloudUPDRS Smartphone Software in Parkinson's Study.
|
N/A | |
| Completed |
NCT02874274 -
Vaccination Uptake (VAX) in PD
|
N/A | |
| Terminated |
NCT02924194 -
Deep Brain Stimulation of the nbM to Treat Mild Cognitive Impairment in Parkinson's Disease
|
N/A |