Rehabilitation of Everyday Memory Impairment in Parkinson Disease: A Pilot Study

Parkinson's Disease Clinical Trial

— REMI-PD  

Official title:

Rehabilitation of Everyday Memory Impairment in Parkinson Disease: A Pilot Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01469741
• Other study ID #: 201103176
• Status: Completed
• Phase: N/A
• First received: November 8, 2011
• Last updated: June 1, 2015
• Start date: June 2011
• Est. completion date: May 2014

Study information

• Verified date: June 2015
• Source: Washington University School of Medicine
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Cognitive impairment is common among non-demented individuals with Parkinson disease (PD) and is a significant source of disability and reduced quality of life. Unfortunately, there are no successful interventions to address these impairments. Prospective memory impairment is a particularly functionally- and clinically-relevant problem in PD. The investigator's project will determine if a targeted intervention strategy improves PD participants' prospective memory. The investigator's goal is to improve PD patients' everyday prospective memory so they can successfully perform desired activities and roles.

Description:

Cognitive impairment is common among non-demented individuals with Parkinson disease (PD) and is a significant source of disability and reduced quality of life. Unfortunately, there are no successful interventions to address these impairments. Prospective memory impairment is a particularly functionally- and clinically-relevant problem in PD. The investigator's project will determine if a targeted intervention strategy improves PD participants' prospective memory. The investigator will use a randomized controlled design and a laboratory-based assessment of prospective memory to test the effect of the strategy in a controlled environment. The investigator will also see if PD participants, with support from an occupational therapist (OT), can generalize the strategy to their complex, real-world environments and tasks. Our goal is to improve PD patients' everyday prospective memory so they can successfully perform desired activities and roles.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 74
• Est. completion date: May 2014
• Est. primary completion date: May 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 50 Years and older

Eligibility

Inclusion Criteria:

• Participants will be males and females over age 50 who meet criteria for idiopathic typical PD, are Hoehn & Yahr39 stage I-III (mild-moderate disease) and are treated with levodopa/carbidopa.

Exclusion Criteria:

• Possible dementia,

• treatment with certain medications that interfere with cognition (e.g., anticholinergics),

• change in medications over the study period, other neurological disorders, brain surgery (e.g., STN DBS),

• history of psychotic disorder or significant current psychiatric disorder, or any condition that would interfere with testing (e.g., vision problems).

Study Design

Intervention Model: Single Group Assignment, Masking: Single Blind (Subject), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

• Parkinson Disease
• Parkinson's Disease

Intervention

Behavioral:
• Prospective Memory Strategy
Prospective memory is central to performance in everyday life as it serves to bind together goal-directed actions and enables people to carry out their plans and wishes meaningfully and appropriately. Everyday prospective memory tasks include remembering to run errands, keep appointments, and turn off the stove after using it.

Locations

Country	Name	City	State
United States	Washington University School of Medicine	St. Louis	Missouri

Sponsors (1)

Lead Sponsor	Collaborator
Washington University School of Medicine

Country where clinical trial is conducted

United States,