Parkinson's Disease Clinical Trial
Official title:
Twins and the Risk of PD: A Clinical and Imaging Study
The purpose of this study is to examine the role of genetic and environmental factors in the cause of Parkinson's disease.
Parkinson's disease (PD) is a growing health problem in the elderly, and genetic factors may
provide substantial clues toward eventual treatment and/or prevention of the disorder. The
National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran
Twins Cohort Registry is one of the few population-based groups of elderly twins. Previous
studies in this group indicated that genetic factors were involved only in early-onset PD,
however there was no follow-up to these studies.
The purpose of the "Twins and the Risk of PD" study is to follow-up previous studies and
confirm the initial findings. In this study, investigators will use the NAS/NRC WWII Veteran
Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic
twins—at least one of whom has PD.
The overall goal of this research is determine the contributions of genetic and
environmental factors in the cause of PD.
The study will involve traditional clinical research methods, such as a clinical
examination, as well as innovative imaging techniques, such as single photon emission
computed tomography (SPECT). SPECT—a nuclear imaging test involving blood flow to tissue—is
used to evaluate certain brain functions.
Findings from this study may help to set research priorities in PD, and to develop tools for
early detection of the disorder.
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Observational Model: Cohort, Time Perspective: Prospective
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